Results 61 to 70 of about 284,765 (244)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Towards Building a Uniform Cloud Database Representation for Data Interchange

Annals of the West University of Timisoara: Mathematics and Computer Science, 2016
The paper proposes design principles for data representation and simplification in order to design cloud services for data exchange between various information systems. We use equivalence algorithms and canonical representation in the cloud database. The
Andreica Alina
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Typology of Stakeholder Interaction and Factors Influencing the Management of Ijen Crater Nature Tourism Park

Jurnal Ilmiah Telsinas
The Ijen Crater Nature Tourism Park (Ijen Crater TWA) is one of the tourist destinations with the enchanting blue fire that is quite famous in East Java and even internationally.
Loetvy Wahyuningtiyas, Syavitri Sukma Utami Rambe, Alifan Cahyana   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Comprehensive Review of Static Memory Analysis

IEEE Access
This review aims to evaluate and compare various static analysis tools across multiple programming languages for memory management. The tools and techniques under scrutiny include pattern matching, symbolic execution, CppCheck, SharpChecker, FindBugs ...
Temidayo Akinyemi, Enoch Solomon, Abraham Woubie, Kari Lippert   +3 more
doaj   +1 more source

Methods for Domain Specification of Verification-Oriented Process Ontology

Моделирование и анализ информационных систем, 2019
User-friendly formal specifications and verification of parallel and distributed systems from various subject fields, such as automatic control, telecommunications, business processes, are active research topics due to its practical significance. In this
Natalia O. Garanina, Igor S. Anureev, Olesya I. Borovikova, Vladimir E. Zyubin   +3 more
doaj   +1 more source

Updates-Aware Graph Pattern based Node Matching [PDF]

, 2020
Guohao Sun, Guanfeng Liu, Yan Wang, Xiaofang Zhou   +3 more
openalex   +1 more source