Results 81 to 90 of about 5,294,225 (254)

Remodeling the light-adapted electroretinogram using a bayesian statistical approach

BMC Research Notes
Objective To present a remodeling of the electroretinogram waveform using a covariance matrix to identify regions of interest and distinction between a control and attention deficit/hyperactivity disorder (ADHD) group. Electroretinograms were recorded in
Marek Brabec, Fernando Marmolejo-Ramos, Lynne Loh, Irene O. Lee, Mikhail Kulyabin, Aleksei Zhdanov, Hugo Posada-Quintero, Dorothy A. Thompson, Paul A. Constable   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

On deformable models for visual pattern recognition

, 2002
This paper reviews model-based methods for non-rigid shape recognition. These methods model, match and classify non-rigid shapes, which are generally problematic for conventional algorithms using rigid models.
Yeung, Dit Yan, Chin, Roland T., Cheung, KW, Yeung, DY, Chin, RT, Cheung, Kwok Wai   +5 more
core   +1 more source

Model-based analysis of pattern motion processing in mouse primary visual cortex [PDF]

, 2015
Neurons in sensory areas of neocortex exhibit responses tuned to specific features of the environment. In visual cortex, information about features such as edges or textures with particular orientations must be integrated to recognize a visual scene or ...
Kampa, Björn M, Morgane M. Roth, Muir, Dylan R, Björn M. Kampa, Roth, Morgane M., Kampa, Björn M., Fritjof Helmchen, Roth, Morgane M, Muir, Dylan R., Dylan R. Muir, Helmchen, Fritjof   +10 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Multimodal Emotion Recognition Based on EEG and EOG Signals Evoked by the Video-Odor Stimuli

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Affective data is the basis of emotion recognition, which is mainly acquired through extrinsic elicitation. To investigate the enhancing effects of multi-sensory stimuli on emotion elicitation and emotion recognition, we designed an experimental paradigm
Minchao Wu, Wei Teng, Cunhang Fan, Shengbing Pei, Ping Li, Guanxiong Pei, Taihao Li, Wen Liang, Zhao Lv   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pattern recognition in industry /

, 2005
"Find it hard to extract and utilise valuable knowledge from the ever-increasing data deluge?" If so, this book will help, as it explores pattern recognition technology and its concomitant role in extracting useful information to build technical and ...
Bhagat, Phiroz.
core