Results 121 to 130 of about 751,464 (275)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Long term outcomes of angle, filtering, and combined angle and filtering surgery for primary congenital glaucoma

JFO Open Ophthalmology
Purpose: To report on long term follow-up of surgical results in primary congenital glaucoma (PCG). Study design: Retrospective chart review. Methods: The charts of all children presenting with and operated on for PCG in Alexandria Main University ...
Nader Bayoumi, Mahmoud Morsy, Mohamed Fouad, Eman Nabil Elsayed   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Personality correlates of type 1 diabetes in a national representative sample

Psychological Topics, 2016
We examined cross-sectional relationships between personality traits and type 1 diabetes. The sample (n=8490) was taken from the 1982-84 wave of the National Health and Nutrition Examination Survey Epidemiological Follow-up Study.
Iva Čukić, Alexander Weiss
doaj   +2 more sources

Pattern of withanolide accumulation in in vitro and field grown tissues quantified using HPTLC.

, 2015
The data presented in the figure are the mean ± standard deviation of three replicates obtained from three independent experiments.
Pankajavalli Thirugnanasambantham (723287), So Hyun Kim (122082), Kalaiselvi Senthil (723286), Hyung Kyoon Choi (723289), Taek Joo Oh (723288)   +4 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Model results for cross pattern experiments. Summary of honeybee behaviour and simulated bees’ performance for the discrimination of simple cross patterns.

, 2017
In the behavioural experiments [11] different groups of honeybees were differentially trained on a particular cross pattern pair, one rewarding (CS+) and one unrewarding (CS-).
Chrisantha Fernando (122774), Mark Roper (3715690), Lars Chittka (27016)   +2 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source