Results 41 to 50 of about 3,670,860 (219)

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Machine learning-based identification of glycolytic-related genes highlights BPGM as a potential therapeutic target in endometriosis

European Journal of Medical Research
Background Endometriosis is a prevalent gynecological disorder characterized by the ectopic growth of endometrial-like tissue, often leading to chronic pelvic pain, infertility, and reduced quality of life.
Linjuan Liu, Jian Zhao, Yu Xi, Qi Liu, Shixing Wu, Jiena Li, Can Chen, Ming He   +7 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Aldosterone-Induced Renal Lymphangiogenesis and Endothelial–To–Mesenchymal Transformation to Promote Renal Interstitial Fibrosis Through the MR/TGF-β1 Pathway in Mice

Frontiers in Bioscience-Landmark
Background: Lymphangiogenesis and phenotypic transformation of endothelial cells are closely associated with the progression of renal interstitial fibrosis.
Lili Fan, Ziqian Liu, Yi Chang, Yunzhao Xiong, Fan Yang, Xiaomeng Gao, Jingyue Chang, Tatsuo Shimosawa, Qingyou Xu, Panpan Qiang   +9 more
doaj   +1 more source

Virtual Monoenergetic CT Imaging via Deep Learning

Patterns, 2020
Summary: Conventional single-spectrum computed tomography (CT) reconstructs a spectrally integrated attenuation image and reveals tissues morphology without any information about the elemental composition of the tissues.
Wenxiang Cong, Yan Xi, Paul Fitzgerald, Bruno De Man, Ge Wang   +4 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Integrated Value of Influence: An Integrative Method for the Identification of the Most Influential Nodes within Networks

Patterns, 2020
Summary: Biological systems are composed of highly complex networks, and decoding the functional significance of individual network components is critical for understanding healthy and diseased states.
Abbas Salavaty, Mirana Ramialison, Peter D. Currie   +2 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Physiology as a Lingua Franca for Clinical Machine Learning

Patterns, 2020
The intersection of medicine and machine learning (ML) has the potential to transform healthcare. We describe how physiology, a foundational discipline of medical training and practice with a rich quantitative history, could serve as a starting point for
Gopal P. Sarma, Erik Reinertsen, Aaron Aguirre, Chris Anderson, Puneet Batra, Seung-Hoan Choi, Paolo Di Achille, Nathaniel Diamant, Patrick Ellinor, Connor Emdin, Akl C. Fahed, Samuel Friedman, Lia Harrington, Jennifer E. Ho, Amit V. Khera, Shaan Khurshid, Marcus Klarqvist, Steve Lubitz, Anthony Philippakis, James Pirruccello, Christopher Reeder, Collin Stultz, Brandon Westover   +22 more
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source