Results 21 to 30 of about 3,670,860 (219)

Esaxerenone inhibits the macrophage-to-myofibroblast transition through mineralocorticoid receptor/TGF-β1 pathway in mice induced with aldosterone

Frontiers in Immunology, 2022
Renal fibrosis is the inevitable pathway of the progression of chronic kidney disease to end-stage renal disease, which manifests as progressive glomerulosclerosis and renal interstitial fibrosis.
Panpan Qiang, Panpan Qiang, Juan Hao, Juan Hao, Fan Yang, Fan Yang, Yutong Han, Yutong Han, Yi Chang, Yi Chang, Yunqian Xian, Yunqian Xian, Yunzhao Xiong, Yunzhao Xiong, Xiaomeng Gao, Xiaomeng Gao, Lijuan Liang, Tatsuo Shimosawa, Qingyou Xu, Qingyou Xu, Qingyou Xu   +20 more
doaj   +1 more source

SRPK2 Expression and Beta-Amyloid Accumulation Are Associated With BV2 Microglia Activation

Frontiers in Integrative Neuroscience, 2022
IntroductionThe extracellular deposition of β-amyloid (Aβ) is a pathological hallmark in Alzheimer's disease (AD), which induces microglial activation in the pathology of AD. The expression of serine/threonine-protein kinase 2 (SRPK2) is increased in the
Ziqi Tian, Wenfang Zeng, Cuihuan Yan, Qiang Li, Nan Li, Lin Ruan, Jie Li, Xiaoguang Yao, Si Li   +8 more
doaj   +1 more source

Predicting hydrogen storage in MOFs via machine learning

Patterns, 2021
Summary: The H2 capacities of a diverse set of 918,734 metal-organic frameworks (MOFs) sourced from 19 databases is predicted via machine learning (ML). Using only 7 structural features as input, ML identifies 8,282 MOFs with the potential to exceed the ...
Alauddin Ahmed, Donald J. Siegel
doaj   +1 more source

Welcome to the revolution: COVID-19 and the democratization of spatial-temporal data

Patterns, 2021
Summary: On January 22, 2020, Johns Hopkins University launched its online COVID-19 dashboard to track in real time what began in December as the regional outbreak of a novel coronavirus first identified in Wuhan, China. The dashboard and its format were
Tom Koch
doaj   +1 more source

Zero-shot personalization of speech foundation models for depressed mood monitoring

Patterns, 2023
Summary: The monitoring of depressed mood plays an important role as a diagnostic tool in psychotherapy. An automated analysis of speech can provide a non-invasive measurement of a patient’s affective state.
Maurice Gerczuk, Andreas Triantafyllopoulos, Shahin Amiriparian, Alexander Kathan, Jonathan Bauer, Matthias Berking, Björn W. Schuller   +6 more
doaj   +1 more source

Meet the authors: Yong Chen, Xiqun (Michael) Chen, and Ziyou Gao

Patterns, 2023
In their recent publication in Patterns, the authors proposed a novel multi-scale unified mobility model to capture the universal-scale laws of individual and population movement within urban agglomerations.
Yong Chen, Xiqun (Michael) Chen, Ziyou Gao   +2 more
doaj   +1 more source

A universal workflow for creation, validation, and generalization of detailed neuronal models

Patterns, 2023
Summary: Detailed single-neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools focus on a limited set of specific features ...
Maria Reva, Christian Rössert, Alexis Arnaudon, Tanguy Damart, Darshan Mandge, Anıl Tuncel, Srikanth Ramaswamy, Henry Markram, Werner Van Geit   +8 more
doaj   +1 more source

Knowledge-driven learning, optimization, and experimental design under uncertainty for materials discovery

Patterns, 2023
Summary: Significant acceleration of the future discovery of novel functional materials requires a fundamental shift from the current materials discovery practice, which is heavily dependent on trial-and-error campaigns and high-throughput screening, to ...
Xiaoning Qian, Byung-Jun Yoon, Raymundo Arróyave, Xiaofeng Qian, Edward R. Dougherty   +4 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source