Results 41 to 50 of about 22,950 (261)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Laboratory Evaluation of Wear Particle Emissions and Suspended Dust in Tire–Asphalt Concrete Pavement Friction

Applied Sciences
This study aims to evaluate the tire–road-wear particles (TRWPs) and suspended dust generated based on the nominal maximum aggregate size (NMAS) of the polymer-modified stone mastic asphalt (SMA) mixtures indoors.
Jongsub Lee, Ohsun Kwon, Yujoong Hwang, Gyumin Yeon   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Pavement Diagnosis as Integrant of the Pavement Management System [PDF]

Communications - Scientific letters of the University of Zilina, 2008
The paper integrates the most important scientific information of the authors in the field of diagnostics of road pavements. Basic attributes of pavement serviceability (evenness, skid resistance) and pavement bearing capacity are the core of the paper. The results of simulations of dynamic systems, outputs of the models developed at the authors place,
Jan Celko, Martin Decky, Jozef Komacka, Matus Kovac   +3 more
openaire   +2 more sources

Developing a multi-scale framework to predict and evaluate cohesion and adhesion of rejuvenated bitumen: Insights from molecular dynamics simulations and experiments

Materials & Design
Rejuvenators are crucial for efficient asphalt pavement recycling, but their effectiveness varies widely based on factors like bitumen source, aging degree, and rejuvenator composition.
Shisong Ren, Marco Poot, Xueyan Liu, Sandra Erkens   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Corrigendum: The use of reflective and permeable pavements as a potential practice for heat island mitigation and stormwater management

Environmental Research Letters, 2013
The full text of this article is available in the PDF provided.
H Li, J T Harvey, T J Holland, M Kayhanian   +3 more
doaj   +1 more source

Non-Newtonian Behaviors of Crumb Rubber-Modified Bituminous Binders

Applied Sciences, 2018
Crumb rubber-modified bitumen (CRMB) has been utilized in the asphalt paving industry for decades due to its various benefits. The complex interaction between bitumen and crumb rubber as well as the addition of warm-mix additives makes the typical laws ...
Haopeng Wang, Xueyan Liu, Panos Apostolidis, Tom Scarpas   +3 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source