Results 51 to 60 of about 273,956 (307)

Public Perceptions of the Midwest\u27s Pavements: Explaining the Relationship Between Pavement Quality and Driver Satisfaction [PDF]

, 2001
A three-phase study involving focus groups and sample surveys was conducted in three Midwestern states to assess the amount of satisfaction that motorists who drive on rural, two-lane state highways have with the pavement characteristics of those ...
Giese, James K., Griffin, Robert, Kuemmel, David   +2 more
core   +1 more source

Sustainable approaches for stormwater quality improvements with experimental geothermal paving systems [PDF]

, 2015
This article has been made available through the Brunel Open Access Publishing Fund.This research assesses the next generation of permeable pavement systems (PPS) incorporating ground source heat pumps (geothermal paving systems).
Clesceri, Hunter, Kiran Tota-Maharaj, Mac Berthouex, Newman, Parneet Paul, Scholz, Scholz, Tota-Maharaj, Tota-Maharaj, Van der Wel, Zhang   +11 more
core   +6 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Laboratory Evaluation of Wear Particle Emissions and Suspended Dust in Tire–Asphalt Concrete Pavement Friction

Applied Sciences
This study aims to evaluate the tire–road-wear particles (TRWPs) and suspended dust generated based on the nominal maximum aggregate size (NMAS) of the polymer-modified stone mastic asphalt (SMA) mixtures indoors.
Jongsub Lee, Ohsun Kwon, Yujoong Hwang, Gyumin Yeon   +3 more
doaj   +1 more source

Structural Performance Assessment of Airfield Concrete Pavements Based on Field and Laboratory Data

Infrastructures, 2021
Maintenance interventions and rehabilitation actions in airfield pavements are time-consuming and adversely affect pavements’ serviceability (i.e., airport closures), with a profound impact on the airport economics.
Konstantinos Gkyrtis, Angeliki Armeni, Christina Plati, Andreas Loizos   +3 more
doaj   +1 more source

Pavement Diagnosis as Integrant of the Pavement Management System [PDF]

Communications - Scientific letters of the University of Zilina, 2008
The paper integrates the most important scientific information of the authors in the field of diagnostics of road pavements. Basic attributes of pavement serviceability (evenness, skid resistance) and pavement bearing capacity are the core of the paper. The results of simulations of dynamic systems, outputs of the models developed at the authors place,
Jan Celko, Martin Decky, Jozef Komacka, Matus Kovac   +3 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source