Results 41 to 50 of about 54,298 (294)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Bumpy Roads Ahead: America's Roughest Rides and Strategies to Make our Roads Smoother [PDF]
, 2013 These days, potholes and pavement deterioration make it a challenge to keep the wheel steady on America's roads and highways. More than a quarter of the nation's major urban roadways -- highways and major streets that are the main routes for commuters ...
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Frontiers in Built Environment, 2022 The pavement management system is recognized as an assertive discipline that works on pavement indices to predict the pavement performance condition. This study used soft computing methods such as genetic algorithms and artificial intelligence to propose
Shadi Hanandeh +3 more
doaj +1 more source
Public Perceptions of the Midwest’s Pavements - Iowa - Phase III [PDF]
, 2001 There are several objectives to this report. The first objective is to describe the sample with regard to the physical pavement data and three measures of driver satisfaction.
Giese, James K. +4 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The Road Pavement Condition Index (PCI) Evaluation and Maintenance: A Case Study of Yemen
Organization, Technology and Management in Construction: An International Journal, 2017 The pavement condition index (PCI) is a simple, convenient and inexpensive way to monitor the condition of the surface of roads, identify maintenance and rehabilitation (M-and-R) needs as well as ensure that road maintenance budgets are spent wisely.
Karim Fareed M.A. +2 more
doaj +1 more source
Results in Engineering, 2021 Due to the high cost associated with pavement roughness monitoring, researches are going on to develop new techniques of pavement monitoring which are cost effective, frequent and easily implementable.
Shohel Rana, Asaduzzaman
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source