Results 31 to 40 of about 9,355,301 (309)

MEPDG Work Plan Task No. 7: Existing Pavement Input Information for the Mechanistic-Empirical Pavement Design Guide, 2009 [PDF]

, 2009
The objective of this study is to systematically evaluate the Iowa Department of Transportation’s (DOT’s) existing Pavement Management Information System (PMIS) with respect to the input information required for Mechanistic-Empirical Pavement Design ...

core  

Review of road pavement performance in various countries [PDF]

Дороги і мости
Introduction. High quality and durable highway pavements are one of the preconditions for the efficient road traffic in every country. Problem Statement. The high-level and scientifical design, construction, maintenance, and rehabilitation of pavement
Altin Seranaj, Diana Bardhi, László Gáspár, Zsolt Bencze   +3 more
doaj   +1 more source

Fatigue Design of Steel Bridge Deck Asphalt Pavement Based on Nonlinear Damage Accumulation Theory

Applied Sciences, 2021
Based on the nonlinear damage theory, this paper aims to explore the fatigue performance of steel bridge deck asphalt pavement under multistage fatigue load.
Xunqian Xu, Yu Li, Wei Huang, Dakai Chen, Chen Zhang, Wenkang Shi   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Design inputs variabilities influence on pavement performance reliability

, 2016
Pavement design is a probabilistic process as it involves many random variables.Through the incorporation of reliability, pavement design methods consider inputparameters variabilities effect on pavement performance.
Yared H. Dinegdae, Björn Birgisson, Birgisson, Björn,, Dinegdae, Yared H.,   +3 more
core   +1 more source

Sustainable Design of Pavements: Predicting Pavement Service Life

Infrastructures
Pavement service life is an important factor that affects both the whole life cost and carbon footprint of a pavement. The service life of a pavement is affected by several different parameters which can be broadly classified into climate conditions ...
Subhendu Bhattacharya, Richard Taylor, Dawid D’Melo, Connor Campbell   +3 more
doaj   +1 more source

Pavement Analysis with the Consideration of Unbound Granular Material Nonlinearity

Designs, 2023
Accurate pavement design and evaluation requires the execution of response analysis. Pavement materials’ behavior does not necessarily conform to the assumptions of the multi-linear elastic theory usually adopted during pavement analysis.
Konstantinos Gkyrtis
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MEPDG Work Plan Task No. 8: Validation of Pavement Performance Curves for the Mechanistic-Empirical Pavement Design Guide, 2009 [PDF]

, 2009
The objective of this research is to determine whether the nationally calibrated performance models used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) provide a reasonable prediction of actual field performance, and if the desired accuracy ...

core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source