Results 51 to 60 of about 148,698 (312)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
DESIGN AND PROPERTIES OF HOT MIXTURE POROUS ASPHALT FOR SEMI-FLEXIBLE PAVEMENT APPLICATIONS [PDF]
, 2005 Semi-flexible pavement consists of selected porous asphalt mixture filled with cementitious slurry. This new type of pavement has prospects to be designed as a high deformation resistant pavement (Setyawan et al, 2001).
Setyawan, Ary
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Design and Sustainability Aspects of Geogrid-Reinforced Flexible Pavements—An Indian Perspective
Frontiers in Built Environment, 2020 Design of flexible pavements is not straightforward when reinforcement materials such as geogrid, geocell, and other types of geosynthetic materials are used in pavement construction.
G. Narendra Goud +5 more
doaj +1 more source
Geotechnics, 2022 Pavement thickness is a very vital component during the design stage of a road construction project. Pavement design helps to determine the costs of the project over a certain period to ascertain how the cost of road pavement construction affect the life
Samuel Y. O. Amakye +2 more
doaj +1 more source
Investigation of AASHTOWare Pavement ME Design/DARWin-MEPerformance Prediction Models for Iowa Pavement Analysis and Design [PDF]
, 2015 The Mechanistic-Empirical Pavement Design Guide (MEPDG) was developed under National Cooperative Highway Research Program (NCHRP) Project 1-37A as a novel mechanistic-empirical procedure for the analysis and design of pavements.
Ceylan, Halil +4 more
core +2 more sources
Pavement Design in the USA [PDF]
MATEC Web of Conferences, 2021 The methodology for calculating pavements used in the United States is discussed in this article. The article contains the principles of pavement design outlined in the manual “P. Design of New and Reconstructed Flexible Pavements. Part 3”, which are used by designers not only in the United States, but also in many countries around the world ...
openaire +2 more sources
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Heliyon, 2018 With the advancement in pavement design and performance analysis procedures, the coefficient of thermal expansion (CTE) of concrete has emerged as a significant design input with a direct impact on concrete pavement performance parameters including ...
Gauhar Sabih +2 more
doaj +1 more source