Results 41 to 50 of about 10,014 (266)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Evaluation of Performance and Challenges of Use of Waste Materials in Pavement Construction: A Critical Review

Applied Sciences, 2019
Paved surfaces must reliably bear heavy loads, often under challenging environmental and geotechnical conditions. These requirements are addressed through the use of high-quality, newly produced materials in pavement design. However, in remote locations,
Ali Jamshidi, Greg White
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Research on Design Method of Long-life Asphalt Pavement

Journal of Materials and Engineering Structures, 2020
In recent years, the problem of early damage of asphalt pavement has been basically solved, and the service performance has been improved, but there are still some deficiencies in design life and service life.
Jinzhao SUN, Shengkun WU, Wenbing ZHU, Yong LU, Hao WU, Yucheng HUANG, Qiang TANG   +6 more
doaj  

Quantifying the impact of coefficient of thermal expansion of overlay concrete on unbonded concrete overlay performance

Heliyon, 2018
With the advancement in pavement design and performance analysis procedures, the coefficient of thermal expansion (CTE) of concrete has emerged as a significant design input with a direct impact on concrete pavement performance parameters including ...
Gauhar Sabih, Tahmidur Rahman, Rafiqul A. Tarefder   +2 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Simultaneous analysis of structural reliability and parameter sensitivity of flexible pavements

Case Studies in Construction Materials
To account for the influence of uncertainties in pavement design, adopting a probabilistic limit state-based approach for asphalt pavement structural design is currently the prevailing solution. However, due to the numerous parameters involved in asphalt
Xiaosi Yang, Hongzhou Zhu, Song Yang, Qiqi Tan, Li Ou   +4 more
doaj   +1 more source

Performance Evaluation of JPCP with Changes of Pavement Mix Design Using Pavement Management Data

Advances in Civil Engineering, 2019
This study aimed to analyze long-term performance of JPCP (jointed plain concrete pavement) according to changes in standard mix design using evaluation of concrete properties based on Korea HPMS (highway pavement management system) and Korea LTPP (long ...
Han Jin Oh, Jun Young Park, Hyung Bae Kim, Won Kyong Jung, Jung Hun Lee   +4 more
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source