Results 71 to 80 of about 148,698 (312)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Simultaneous analysis of structural reliability and parameter sensitivity of flexible pavements

Case Studies in Construction Materials
To account for the influence of uncertainties in pavement design, adopting a probabilistic limit state-based approach for asphalt pavement structural design is currently the prevailing solution. However, due to the numerous parameters involved in asphalt
Xiaosi Yang, Hongzhou Zhu, Song Yang, Qiqi Tan, Li Ou   +4 more
doaj   +1 more source

Perpetual Pavement Instrumentation for the Marquette Interchange Project-Phase 1 [PDF]

, 2007
This report provides details on the design, installation and monitoring of a pavement instrumentation system for the analysis of load-induced stresses and strains within a perpetual HMA pavement system.
Crovetti, James, Hornyak, Nicholas James, Newman, David, Schabelski, Jay   +3 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Thermal Behavior of Concrete: Understanding the Influence of Coefficient of Thermal Expansion of Concrete on Rigid Pavements

Applied Sciences
Concrete’s coefficient of thermal expansion (CTE) is a critical property affecting the durability and performance of rigid pavements. This review paper examines the significance of CTE in pavement design and the factors influencing it, including the type
Alka Subedi, Hyunhwan Kim, Moon-Sup Lee, Soon-Jae Lee   +3 more
doaj   +1 more source

Using the mechanistic-empirical pavement design guide for material selection

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
The general design approach in the Mechanistic-Empirical pavement Design Guide (MEPDG) is to compare the performance of several trail structures over the design period against previously defined performance criteria to choice the best alternative after ...
Armando Orobio, John P. Zaniewski
doaj   +1 more source

Performance of Tencate Mirafi PGM-G4 Interlayer-Reinforced Asphalt Pavements in Alaska [PDF]

, 2014
Geosynthetics has been used in hot mix asphalt (HMA) overlays in a variety of design and construction situations for more than three decades. A number of positive benefits have been identified such as waterproofing control for base and subgrade ...
Eckman, Paul, Li, Peng, Liu, Jenny
core  

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Flexible Pavement Evaluation: A Case Study

Kurdistan Journal of Applied Research, 2017
This study is a survey to evaluate the flexible pavement conditions to determine and specify the types of the failures in the pavement for the selected highway.
Shamil Ahmed Flamarz Al-Arkawazi
doaj   +1 more source

Optimizing In-Place Density of Asphalt Pavements During Cold Weather Paving in Nebraska [PDF]

, 2019
Late season paving is common and often performed in colder temperatures, which is the most challenging environment for attaining optimal in-place density/compaction The in-place density of asphalt pavement greatly affects the lifespan of the pavement. It
Haghshenas, Hamzeh, Rea, Robert C.
core   +1 more source