Results 71 to 80 of about 146,603 (293)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Thermal modeling of Anchorage driveway culvert with addition of insulation to prevent frost heaving [PDF]

open access: yes, 2017
A predominate problem in cold regions, and specifically in Anchorage, Alaska, is frost heaving pavement above culverts in residential driveways. The culvert increases heat loss in the subgrade materials during winter months and allows the soils below ...
Banzhaf, Clinton J.
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Design and Economic Analysis of a Flexible Pavement on a Geosynthetic Reinforced Subgrade

open access: yesJournal of Applied Sciences and Environmental Management, 2019
This study investigated the effect of geogrid reinforcement on the  mechanical property of an unsuitable road soil with respect to appropriate placement in the pavement structure and implication on the cost of the development of the road.
GA Ogunkunbi, YA Jimoh
doaj   +1 more source

Performance Evaluation of Open Graded Base Course with Doweled and Non-Doweled Transverse Joints [PDF]

open access: yes, 2010
The objectives of this study were to investigate the performance of 20-year old doweled/non-doweled and dense-graded/permeable base test sections on three concrete pavement segments in Wisconsin: USH 18/151 in Iowa and Dane counties, STH 29 in Brown ...
Crovetti, James   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

PERENCANAAN DESAIN PERKERASAN KAKU (RIGID PAVEMENT) MENGGUNAKAN METODE BINA MARGA 2017 DAN AASHTO 1993 JALAN TOL SERPONG – BALARAJA SEKSI 1B STA 5+150 – STA 9+845 [PDF]

open access: yes
This final assignment examines rigid pavement on toll roads. The purpose of this planning is to plan the pavement design and budget the costs that need to be incurred in toll road planning.
Irawan, Arif Budi
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Evaluation of Climatic Factors Based on the Mechanistic -Empirical Pavement Design Guide

open access: yesThe Baltic Journal of Road and Bridge Engineering, 2013
In this paper procedure for evaluating the effects of climate on pavement performance in Italy is proposed. To characterize the Italian territory nine different simulated scenarios have been used.
Daiva Žilionienė   +2 more
doaj   +1 more source

Guidance for Improving Foundation Layers to Increase Pavement Performance on Local Roads, TR-640, 2014 [PDF]

open access: yes, 2014
This document is the second of two deliverables for the project Optimizing Pavement Base, Subbase, and Subgrade Layers for Cost and Performance on Local Roads (TR-640). The first deliverable is the 454-page Final Field Data Report.

core  

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