Results 21 to 30 of about 178 (122)
PAX3-FOXO1 escapes miR-495 regulation during muscle differentiation [PDF]
RNA Biology, 2019 Pax3 plays an essential role in myogenesis. Previously, we found a tumor-signature chimeric fusion RNA, PAX3-FOXO1 also present during muscle differentiation, raising the possibility of its physiological role. Here we demonstrated that the fusion is needed transiently for muscle lineage commitment.
Zhongqiu, Xie +5 more
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IRIZIO : a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS) [PDF]
Carcinogenesis, 2010 Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children with an annual incidence of five new cases per million. Alveolar rhabdomyosarcoma (ARMS) is characterized by the t(2;13) or t(1;13) chromosomal translocations, which generate the PAX3-FOXO1 or PAX7-FOXO1 fusion genes, respectively.
Fabrizio, Picchione +4 more
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Molecular Oncology, 2020 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1
Lays M. Sobral +8 more
doaj +1 more source
The hunt for a PAX3‐FOXO1 motif (939.4)
The FASEB Journal, 2014 Alveolar Rhabdomyosarcoma (ARMS) patients carrying a chromosomal translocation of PAX3 and FOXO1 have the highest mortality rates, indicating the importance of understanding how this transcription factor influences gene expression. Many studies have been performed to identify PAX3‐FOXO1 target genes and while some overlapping gene sets have been ...
Kelly Johanson +3 more
openaire +1 more source
Nature Communications, 2021 Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors.
Dominik Laubscher +20 more
doaj +1 more source
Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma [PDF]
Molecular Cancer Therapeutics, 2018 Abstract Alveolar rhabdomyosarcoma (ARMS) patients have a poor prognosis, and this is primarily due to overexpression of the oncogenic fusion protein PAX3-FOXO1. Results of RNA-sequencing studies show that PAX3-FOXO1 represses expression of interleukin-24 (IL24), and these two genes are inversely expressed in patient tumors.
Alexandra Lacey +5 more
openaire +2 more sources
BMC Cancer, 2019 Background Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been elucidated yet.
Gwan Hee Han +5 more
doaj +1 more source
A call to ARMS: targeting thePAX3-FOXO1gene in alveolar rhabdomyosarcoma [PDF]
Expert Opinion on Therapeutic Targets, 2013 Expression of fusion oncoproteins generated by recurrent chromosomal translocations represents a major tumorigenic mechanism characteristic of multiple cancers, including one-third of all sarcomas. Oncogenic fusion genes provide novel targets for therapeutic intervention.
Mary E, Olanich, Frederic G, Barr
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Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma
Oncology Reports, 2013 Rhabdomyosarcoma (RMS) is a soft tissue sarcoma categorized into two major subtypes: alveolar RMS (ARMS) and embryonal RMS (ERMS). Most ARMS express the PAX3-FOXO1 (P3F) fusion oncoprotein generated by the 2;13 chromosomal translocation. In the present study, the downstream target genes of P3F were identified by analyzing two independent sets of gene ...
AHN, EUN HYUN +3 more
openaire +3 more sources
Diagnostic Pathology, 2019 Background The most frequent histological types of rhabdomyosarcoma (RMS) in children are embryonal (ERMS) and alveolar (ARMS) tumours. The majority of ARMS are characterized by the presence of PAX3/7-FOXO1 gene fusion and have a worse prognosis than ...
Magdalena Kaleta +6 more
doaj +1 more source