Results 1 to 10 of about 38,355 (234)

FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice

Molecular Metabolism, 2021
Objective: Forkhead box protein O1 (FOXO1) plays a key role in regulating hepatic glucose production, but investigations of FOXO1 inhibition as a potential therapeutic approach have been hampered by a lack of selective chemical inhibitors.
Hua V Lin, Yun-Kyoung Lee, Rudolph Leibel   +2 more
exaly   +3 more sources

Forkhead Box O1 Promotes Osteogenesis of Periodontal Ligament Stem Cells Via Glycolysis-Related Metabolic Reprogramming [PDF]

International Dental Journal
Introduction and aims: Predictable periodontal regeneration is limited by variability in the osteogenic capacity of candidate cell sources. This study aimed to investigate whether forkhead box O1 (FoxO1) enhances the osteogenic differentiation of ...
Jiaxin Zou, Jiang Guo, Qian Zeng, Zhuoyao Liang, Luchen Gui, Xiaojun Huang, Jiacheng Lin   +6 more
doaj   +2 more sources

FOXO1 transcription factor modulates airway epithelial responses to viral infection. [PDF]

PLoS ONE
The airway epithelium serves as the initial barrier of defence in the respiratory system, guarding against microbial, chemical, and environmental threats introduced through inhaled air.
Nadia M Daniel, Ritu Mann-Nüttel, Nami Shrestha Palikhe, Joaquin López-Orozco, Tom Hobman, Paul Forsythe, Harissios Vliagoftis   +6 more
doaj   +2 more sources

A Pax7::Foxo1 conditional mouse strain [PDF]

Skeletal Muscle
Background The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological ...
G. Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D. Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider, Gillian St. John, Samuel V. Rasmussen, Narendra Bharathy, Charles Keller   +13 more
doaj   +2 more sources

Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1 [PDF]

Journal of Medical Biochemistry, 2023
Background: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). Methods: Serum levels of CASC11 and FoxO1 in DN patients were detected.
Zhang Yun, Shi Shuhan, Lin Changda, Che Lishuang, Li Yuangen, Zeng Quanzuan, Lin Weiyuan   +6 more
doaj   +1 more source

The effect of metformin along with high-intensity interval training on gene expression of FoxO1 and Atrogin-1 in type 2 diabetic mice [PDF]

Journal of Shahrekord University of Medical Sciences, 2023
Background and aims: Muscle atrophy is a complication of type 2 diabetes, in which the expression of atrophy-related genes is increased. The present study aimed to investigate the effect of high-intensity interval training (HIIT) and metformin on gene ...
Atefeh Rahimi, Maryam Delfan, Seed Daneshyar   +2 more
doaj   +1 more source

Effects of phosphorylation sites of FoxO1 on protein synthesis and proteolysis in rat skeletal muscle cells exposure to hypoxia

Di-san junyi daxue xuebao, 2020
Objective To investigate the effects of different phosphorylation sites of FoxO1 on protein synthesis and proteolysis in rat skeletal muscle L6 cells under the condition of hypoxia.
JIA Jie, FU Pengyu, ZHU Rongxin, XU Chunyan2, GONG Lijing   +4 more
doaj   +1 more source

MicroRNA-486-5p suppresses inflammatory response by targeting FOXO1 in MSU-treated macrophages

Autoimmunity, 2022
Gouty arthritis (GA) is mainly caused by the precipitation of monosodium urate (MSU) crystals in the joint. Recently, different regulatory roles of microRNAs (miRNAs) in arthritis have been widely verified. Nevertheless, the specific function of microRNA-
Jianguo Hu, Cheng Jin, Li Fang, Yao Lu, Yanying Wu, Xiangfeng Xu, Simei Sun   +6 more
doaj   +1 more source

Acupuncture Targeting SIRT1 in the Hypothalamic Arcuate Nucleus Can Improve Obesity in High-Fat-Diet-Induced Rats with Insulin Resistance via an Anorectic Effect

Obesity Facts, 2020
Objective: To investigate the anorexigenic and anti-obesity effectiveness of electroacupuncture (EA) on high-fat-diet-induced (HFDI) obese rats with insulin resistance (IR) and to reveal the possible mechanisms of EA affecting SIRT1 (silent mating type ...
Qing Shu, Li Chen, Song Wu, Jia Li, Jianmin Liu, Ling Xiao, Rui Chen, Fengxia Liang   +7 more
doaj   +1 more source

MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation [PDF]

Clinical and Molecular Hepatology
Background/Aims Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and abnormal MET expression plays a crucial role in its progression. However, the specific pathogenic mechanisms of MET in HCC have yet to be fully elucidated.
Tiantian Wang, Dean Rao, Chenan Fu, Zhoubin Sun, Yiming Luo, Junli Lu, Jie Jin, Han Li, Feimu Fan, Huifang Liang, Wenjie Huang, Limin Xia   +11 more
doaj   +1 more source