Results 21 to 30 of about 38,355 (234)
Role of LncRNA H19 in promoting endometrial deciduation
陆军军医大学学报, 2023 Objective To explore the effect of LncRNA H19 on endometrial decidualization. Methods The expression of LncRNA H19 in decidual tissues of spontaneous abortion and induced abortion was detected by RT-qPCR; The expression of LncRNA H19 in non-pregnant ...
WANG Tingting +4 more
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Effect of miR-581 on Autophagy of Ovarian Cancer SKOV3 Cells by Regulating FOXO1
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the effect and mechanism of miR-581 on the autophagy of ovarian cancer SKOV3 cells. Methods miR-581 mimics and miR-581 NC were transfected into SKOV3 cells, and the transfection efficiency was detected by qRT-PCR.
GAO Haining +4 more
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Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter [PDF]
Cell Death & Disease, 2020 AbstractPoly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcription in a polymerase ...
Tian, Yu-Nan +4 more
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Dermato-Endocrinology, 2011 Oral isotretinoin (13-cis retinoic acid) is the most effective drug in the treatment of acne and restores all major pathogenetic factors of acne vulgaris. isotretinoin is regarded as a prodrug which after isomerizisation to all-trans-retinoic acid (ATRA) induces apoptosis in cells cultured from human sebaceous glands, meibomian glands, neuroblastoma ...
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FoxO1 as a tissue-specific therapeutic target for type 2 diabetes
Frontiers in Endocrinology, 2023 Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of physiology and thus have been targeted as therapeutics for several diseases including metabolic disorders such as type 2 diabetes mellitus (T2D).
Nicole A. Teaney +2 more
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Breast Cancer: Targets and Therapy, 2023 Jinling Yu,1 Haofeng Wang,1 Weida Shen,1 Yingzi Zhou,2 Jing Cui,1 Haichuan Li,3 Beimin Gao1 1Department of Breast Surgery, Shanghai Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, 200050, People’s Republic of China;
Yu J +6 more
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Journal of Advanced Research, 2021 Introduction: The proliferation of vascular smooth muscle cells (VSMCs) is an important physiological and pathological basis for many cardiovascular diseases.
Xiaoyu Tian +12 more
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The Roles of FOXO1 in Periodontal Homeostasis and Disease [PDF]
Journal of Immunology Research, 2021 Periodontitis is an oral chronic inflammatory disease that is initiated by periodontal microbial communities and requires disruption of the homeostatic responses. The prevalence of periodontal disease increases with age; more than 70% of adults 65 years and older have periodontal disease.
Liang Ren +4 more
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Inhibition of Sodium-Glucose Cotransporter-2 during Serum Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO Signaling Pathway [PDF]
Endocrinology and MetabolismBackground Sodium-dependent glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in the renal proximal tubules, and SGLT2 inhibitors are used as therapeutic agents for treating type 2 diabetes mellitus.
Jinmi Lee +8 more
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The Journal of Poultry Science, 2017 The expression of atrogin-1/MAFbx, a muscle-specific E3 ubiquitin ligase, is increased in catabolic conditions that result in muscle atrophy. The expression of atrogin-1/MAFbx mRNA is also decreased by the insulin-like growth factor-I (IGF-I) in ...
Kazuki Nakashima +4 more
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