Results 31 to 40 of about 38,355 (234)

Protective effect of bone marrow mesenchymal stem cells modified with klotho on renal ischemia-reperfusion injury

Renal Failure, 2019
Objective: To detect the combination protective effect of bone marrow mesenchymal stem cells (BMSCs) and Klotho gene on the renal ischemia-reperfusion injury (RIRI). Methods: BMSCs isolated from rats were transfected with Klotho gene to form BMSCKl.
Li-Bo Xie, Xi Chen, Bo Chen, Xian-Ding Wang, Rui Jiang, Yi-Ping Lu   +5 more
doaj   +1 more source

Dynamic monitoring of cognitive impairment and prognostic recurrence risk in patients with stroke by serum HDAC3 and FOXO1: A potential diagnostic approach [PDF]

Journal of Medical Biochemistry
Background: To evaluate the clinical value of dynamically monitoring serum histone deacetylase 3 (HDAC3) and forkhead box protein O1 (FOXO1) levels in evaluating cognitive impairment (CI) in cerebral stroke (CS) patients, to enable early identification ...
Liu Xintong, Wang Lulu, Xiao Bin, Liu Zhengkun, Dou Yue   +4 more
doaj   +1 more source

Expression of FOXO1 in Liver Cancer and Its Prognostic Significance: An Analysis Based on TCGA

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the expression and prognostic value of FOXO1 gene in liver cancer tissues based on TCGA and HPA databases. Methods The RNA-seq data of FOXO1 gene in liver cancer were downloaded from TCGA.
YANG Tingfang, WANG Li, ZHANG Yong
doaj   +1 more source

FOXO1 overexpression and loss of pSerine256-FOXO1 expression predicts clinical outcome in esophageal adenocarcinomas [PDF]

Scientific Reports, 2018
AbstractThe function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a tissue microarray containing more than 600 esophageal cancers was analyzed.
Grupp, Katharina, Uzunoglu, Faik Güntac, Melling, Nathaniel, Hofmann, Bianca, El Gammal, Alexander Tarek, Grotelüschen, Rainer, Heumann, Asmus, Bellon, Eugen, Reeh, Matthias, Wolters-Eisfeld, Gerrit, Ghabdan, Tarik, Nentwich, Michael, Bachmann, Kai, Bockhorn, Maximillian, Bogoevski, Dean, Izbicki, Jakob Robert, Kutup, Asad   +16 more
openaire   +2 more sources

Expression of FOXO1, FOXO3 and BECN1 genes in peripheral blood leukocytes in chronic course of pulmonary sarcoidosis

Инфекция и иммунитет
Among the FOXO (Forkhead box O) family proteins, which are the most studied and widely represented in various human organs and tissues, transcription factors FOXO1 and FOXO3 are of special importance. Numerous studies evidence about their crucial role in
Irina E. Malysheva, Olga V. Balan, Ella L. Tikhonovich   +2 more
doaj   +1 more source

Role of FoxO1 in Acne and Effect of Isotretinoin on FoxO1 Expression

Indian Dermatology Online Journal
Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating
Parul Kamboj, Geeti Khullar, Sanjeev Handa, Arnab Pal, Uma Nahar Saikia, Dipankar De   +5 more
openaire   +3 more sources

COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression [PDF]

Journal of Biological Chemistry, 2008
COP1 is a Ring-Finger E3 ubiquitin ligase that is involved in plant development, mammalian cell survival, growth, and metabolism. Here we report that COP1, whose expression is enhanced by insulin, regulates FoxO1 protein stability. We found that in Fao hepatoma cells, ectopic expression of COP1 decreased, whereas knockdown of COP1 expression increased ...
Satomi, Kato, Jixin, Ding, Evan, Pisck, Ulupi S, Jhala, Keyong, Du   +4 more
openaire   +2 more sources

Cyclin-dependent kinase 4 phosphorylates and positively regulates PAX3-FOXO1 in human alveolar rhabdomyosarcoma cells. [PDF]

PLoS ONE, 2013
Alveolar rhabdomyosarcoma (ARMS) is an aggressive childhood muscle sarcoma with a 5-year survival rate of less than 30%. More than 80% of ARMSs harbor a PAX3-FOXO1 fusion transcription factor.
Lingling Liu, Jing Wu, Su Sien Ong, Taosheng Chen   +3 more
doaj   +1 more source

FOXO1 modulates osteoblast differentiation

Bone, 2011
Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F, Flowers, Stephen, Bhattacharya, Rupa, Faibish, Dan, Behl, Yugal, Kotton, Darrell N, Gerstenfeld, Lou, Moran, Elizabeth, Graves, Dana T   +8 more
openaire   +4 more sources

Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications

Cells, 2019
Background: The present study was designed to explore the underlying role of hypoxia-inducible factor 1α (HIF-1α) in reactive oxygen species (ROS) formation and apoptosis in osteosarcoma (OS) cells induced by hypoxia.
Wei Sun, Bing Wang, Xing-Long Qu, Bi-Qiang Zheng, Wen-Ding Huang, Zheng-Wang Sun, Chun-Meng Wang, Yong Chen   +7 more
doaj   +1 more source