Results 11 to 20 of about 38,355 (234)
Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs [PDF]
PLOS Genetics, 2021 The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models.
Line Manceau +5 more
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FoxO1 in embryonic development [PDF]
Transcription, 2012 Establishment of the maternal-fetal circulation during embryonic development is a fundamental process required for effective exchange of nutrients, waste products and signaling factors critical to all subsequent stages of fetal growth and development.
Anwarul, Ferdous, Joseph A, Hill
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Cancer Cell, 2005 Skp2 is an oncoprotein that mediates the degradation of several negative regulators of the cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the FoxO family of transcription factors.
Dehan, Elinor, Pagano, Michele
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Foxo1 and Foxo3 help Foxp3 [PDF]
Immunity, 2010 In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
Ohkura, Naganari, Sakaguchi, Shimon
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FoxO1 breaks diabetic heart [PDF]
Journal of Diabetes Investigation, 2012 The incidence of type 2 diabetes is increasing explosively around the world. Both hyperglycemia and insulin resistance can cause myocardial damages with coronary atherosclerosis in type 2 diabetes. In addition, some patients show cardiac functional disorder, characterized by diastolic dysfunction, without ischemia.
Nagao, Mototsugu +2 more
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Putting the brakes on FOXO1 in fat [PDF]
The EMBO Journal, 2012 The Foxo1 forkhead transcription factor is a critical negative regulator of insulin action. In this issue of The EMBO Journal , Nakae and colleagues (Nakae et al , 2012) describe a novel Foxo1 Co‐Repressor (FCoR) protein in adipocytes, showing that FCoR enhances the acetylation of Foxo1 to inhibit Foxo1 activity, promote adipocyte differentiation ...
Jane J, Kim +2 more
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Foxo1 in hepatic lipid metabolism [PDF]
Cell Cycle, 2010 This division of labor is thought to contribute to the hypergly-cemia (inhibition of IRS2 signaling) and the paradoxical lipid accumulation (sus-tained IRS1 signaling) in type 2 diabetes. Regardless, recent work with genetically modified mice shows that both IRS1 and IRS2 are strong inhibitors of FoxO1,
Zhiyong, Cheng, Morris F, White
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European Journal of Breast Health, 2022 Objective:Breast cancer (BC) is the most prevalent female cancer globally and this is also true in Iranian women. Alteration in circulating microRNAs affects the fate of immune cells, affecting immunological response to neoplasia.Materials and Methods:We
Farhad Seif +6 more
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FoxO1 and hepatic lipid metabolism [PDF]
Current Opinion in Lipidology, 2009 PURPOSE OF REVIEW: This review summarizes recent research implicating Forkhead box (Fox)O1, a key transcription factor in glucose metabolism, in the regulation of hepatic lipid metabolism. Insulin dysregulation leading to hypertriglyceridemia is associated with increased hepatic VLDL secretion.
Janet D, Sparks, Henry H, Dong
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Pharmaceutical Biology, 2020 Context Recent studies have shown compound Danshen dripping pills (CDDP) could improve microcirculation in ischemic/reperfusion injury and other microvascular disorders. The mechanism for CDDP’s role in microcirculation is not clear. Objective To explore
Yanda Zhang +5 more
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