Results 141 to 150 of about 8,051 (168)
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The oncogenic transcription factor PAX3-FKHR can convert fibroblasts into contractile myotubes
Experimental Cell Research, 2007PAX3-FKHR, the product of a rearrangement of PAX3 with FKHR is the pathogenetic marker for alveolar rhabdomyosarcoma, an aggressive form of childhood cancer. In this work we show that PAX3-FKHR, which is a stronger transcriptional activator relative to PAX3, can lead to two apparently irreconcilable outcomes: transformation and terminal myogenic ...
Paolo E Forni +2 more
exaly +3 more sources
Developmental Biology, 2008 Pax3 is expressed early during embryonic development in spatially restricted domains including limb muscle, neural crest, and neural tube. Pax3 functions at the nodal point in melanocyte stem cell differentiation, cardiogenesis and neurogenesis. Additionally Pax3 has been implicated in migration and differentiation of precursor cell populations ...
Tadanori Tomita
exaly +3 more sources
International Journal of Biochemistry and Cell Biology, 2010
The transcription factor, Pax3, alters transcription by binding directly to promoter regions harbouring sequences recognized by either its paired domain or its homeodomain. We demonstrated previously that the promoter regions of many of the genes whose expression was altered during a Pax3-induced mesenchymal-to-epithelial transition harboured sequences
Tania Christova
exaly +3 more sources
The transcription factor, Pax3, alters transcription by binding directly to promoter regions harbouring sequences recognized by either its paired domain or its homeodomain. We demonstrated previously that the promoter regions of many of the genes whose expression was altered during a Pax3-induced mesenchymal-to-epithelial transition harboured sequences
Tania Christova
exaly +3 more sources
Human Genetics, 2000
Waardenburg syndrome (WS) is associated with neural crest-derived melanocyte deficiency caused by mutations in either one of three transcription factors: MITF, PAX3, and SOX10. However, the hierarchical relationship of these transcription factors is largely unknown.
S B, Potterf +4 more
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Waardenburg syndrome (WS) is associated with neural crest-derived melanocyte deficiency caused by mutations in either one of three transcription factors: MITF, PAX3, and SOX10. However, the hierarchical relationship of these transcription factors is largely unknown.
S B, Potterf +4 more
openaire +2 more sources
Neuromuscular Disorders, 2012
Abstract Pax3 is a member of paired box (Pax) family and considered to play an important role in the initial stage of skeletal muscle development. However, its precise function of myogenesis in vitro and in vivo remains unknown. For example, how Pax3 affect the expression of myogenic regulatory factors (MRFs) has not yet been clarified.
H. Hagiwara +6 more
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Abstract Pax3 is a member of paired box (Pax) family and considered to play an important role in the initial stage of skeletal muscle development. However, its precise function of myogenesis in vitro and in vivo remains unknown. For example, how Pax3 affect the expression of myogenic regulatory factors (MRFs) has not yet been clarified.
H. Hagiwara +6 more
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Melanoma Research, 2005
The objective of this study was to determine which transcription factors regulate the expression of the Pax3 gene in the mouse B16 F1 melanoma cell line. The results showed that the -14 kilobase pair (kbp) Pax3 promoter, but not the -1.6 kbp Pax3 promoter, promoted Pax3 gene expression in B16 cells.
Bi-ke, Zhu, Steven C, Pruitt
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The objective of this study was to determine which transcription factors regulate the expression of the Pax3 gene in the mouse B16 F1 melanoma cell line. The results showed that the -14 kilobase pair (kbp) Pax3 promoter, but not the -1.6 kbp Pax3 promoter, promoted Pax3 gene expression in B16 cells.
Bi-ke, Zhu, Steven C, Pruitt
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Cancer research, 1993
Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14). This translocation is associated with a structural rearrangement of the gene encoding PAX3, a presumed transcriptional regulator expressed exclusively during embryogenesis.
D N, Shapiro +4 more
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Alveolar rhabdomyosarcoma, a malignant tumor of skeletal muscle, is characterized by a chromosomal translocation, t(2;13)(q35;q14). This translocation is associated with a structural rearrangement of the gene encoding PAX3, a presumed transcriptional regulator expressed exclusively during embryogenesis.
D N, Shapiro +4 more
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1284 The transcription factor pax3 as a regulator of nonsense-mediated decay in melanoma
Journal of Investigative Dermatology, 2023N.B. Prince +4 more
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[Role of the transcription factor PAX3 during myogenesis: from the embryo to the adult stage].
Medecine sciences : M/SPAX3 plays a crucial role in embryonic myogenesis, controlling the specification, migration, proliferation, and differentiation of muscle progenitor cells to ensure normal skeletal muscle development in the embryo. However, PAX3 potential role in a context of muscle homeostasis and regeneration remains poorly investigated.
Virginia, Zoglio +2 more
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Functional Analyses of Alternative Isoforms of the Transcription Factor PAX3 in Melanocytes
Melanoma Research, 2004Q. Wang, C. Parker, S. Kumar, P. Kumar
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