Results 1 to 10 of about 20,380 (169)

PAX6 disease models for aniridia

Indian Journal of Ophthalmology, 2022
Aniridia is a pan-ocular genetic developmental eye disorder characterized by complete or partial iris and foveal hypoplasia, for which there is no treatment currently.
Dorsa Abdolkarimi, Dulce Lima Cunha, Manuela Lahne, Mariya Moosajee   +3 more
doaj   +4 more sources

Pax6 as a Therapeutic Target: Convergent Molecular Pathways in the Regulation of Aniridia, Neurogenesis, Neurodegeneration and Oncology [PDF]

Cells
Pax6 is a multifunctional transcription factor that orchestrates cell cycle progression at distinct stages of early embryonic neurogenesis and serves as a molecular mediator integrating multiple signaling pathways associated with pathological processes ...
Marina Skorkina, Tatiana Kovaleva, Irina Predeina, Nikita Smirnov, Irina Mukhina   +4 more
doaj   +2 more sources

PAX6 Downregulation Triggers HIF-1α-Mediated Ferroptosis in Glioma Cells [PDF]

Biomolecules
Background: The paired-box gene 6 (PAX6) is an important transcription factor in the central nervous system, mainly regulating the development and differentiation of embryonic eyes and the nervous system.
Qizhi Luo, Li Fu, Jie Zhang, Shashuang Zhang, Lixiang Wu, Quan Zhu, Baisheng Huang   +6 more
doaj   +2 more sources

Clinical and molecular aspects of congenital aniridia – A review of current concepts

Indian Journal of Ophthalmology, 2022
Congenital aniridia is a pan ocular disorder characterized by partial or total loss of iris tissue as the defining feature. Classic aniridia, however, has a spectrum of ocular findings, including foveal hypoplasia, optic nerve hypoplasia, nystagmus, late-
Shailja Tibrewal, Ria Ratna, Abha Gour, Sumita Agarkar, Suneeta Dubey, Suma Ganesh, Ramesh Kekunnaya, Virender Sangwan, Yutao Liu, Vanita Vanita   +9 more
doaj   +1 more source

3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes. [PDF]

PLoS ONE, 2012
Pax6 and Pax6(5a) are two isoforms of the evolutionary conserved Pax6 gene often co-expressed in specific stochiometric relationship in the brain and the eye during development.
Yury Kiselev, Tonje Engevik Eriksen, Siri Forsdahl, Lan Huong Thi Nguyen, Ingvild Mikkola   +4 more
doaj   +1 more source

circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis

Open Medicine, 2022
Circular RNAs (circRNAs) serve as essential players in diverse human cancers, including retinoblastoma (RB). In this study, the function of circRNA Ring Finger Protein 20 (circRNF20) in RB progression was investigated.
An Dexiang, Yang Jing, Ma Linli
doaj   +1 more source

The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid. [PDF]

PLoS ONE, 2013
Pax6 is a pivotal transcription factor that plays a role during early eye morphogenesis, but its expression and function in eyelid development remain unknown. In this study, the expression patterns of Pax6 mRNA and protein were examined in the developing
Fangyu Shi, Yannan Fan, Laiguang Zhang, Lu Meng, Huifang Zhi, Hongyu Hu, Aixin Lin   +6 more
doaj   +1 more source

Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel

Frontiers in Cell and Developmental Biology, 2022
Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the ...
Léo Michel, Karina Palma, Karina Palma, Mauricio Cerda, Mauricio Cerda, Mauricio Cerda, Ronan Lagadec, Hélène Mayeur, Michaël Fuentès, Laurence Besseau, Patrick Martin, Elodie Magnanou, Patrick Blader, Miguel L. Concha, Miguel L. Concha, Miguel L. Concha, Sylvie Mazan   +16 more
doaj   +1 more source

A Case of Autosomal Dominant Bilateral Familial Aniridia

GAIMS Journal of Medical Sciences, 2021
Aniridia is a familial or sporadic disorder affecting not only the iris but also the cornea, angle structures, lens, optic nerve, and fovea. This disorder may be associated with many other systemic abnormalities such as urogenital malignancies. We report
Kinjal Mehta, Nikhil Rupala, Kavita Shah
doaj   +1 more source

Neurogenesis during Brittle Star Arm Regeneration Is Characterised by a Conserved Set of Key Developmental Genes

Biology, 2022
Neural regeneration is very limited in humans but extremely efficient in echinoderms. The brittle star Amphiura filiformis can regenerate both components of its central nervous system as well as the peripheral system, and understanding the molecular ...
Anna Czarkwiani, Jack Taylor, Paola Oliveri   +2 more
doaj   +1 more source