Results 121 to 130 of about 36,753 (224)

Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro.

PLoS ONE
PurposeIn the present study, we evaluate gene and protein expression levels in an in vitro siRNA-mediated PAX6 knockdown limbal epithelial cell (LEC) model after RA treatment.
Shao-Lun Hsu, Tanja Stachon, Fabian N Fries, Zhen Li, Shuailin Li, Shanhe Liu, Berthold Seitz, Swarnali Kundu, Maryam Amini, Shweta Suiwal, Nóra Szentmáry   +10 more
doaj   +1 more source

The Role of Pax6 in Brain Patterning.

The Tohoku Journal of Experimental Medicine, 2001
Pax6 g ene encodes a transcription factor that plays a pivotal role in various aspects of brain development. Here I review the molecular and cellular mechanisms of how the early brain is patterned, and introduce recent studies on the role of Pax6 in brain patterning, neuronal specification, neuronal migration and axonal extension.
openaire   +3 more sources

H3 Acetylation-Induced Basal Progenitor Generation and Neocortex Expansion Depends on the Transcription Factor Pax6

Biology
Enrichment of basal progenitors (BPs) in the developing neocortex is a central driver of cortical enlargement. The transcription factor Pax6 is known as an essential regulator in generation of BPs.
Godwin Sokpor, Cemil Kerimoglu, Pauline Antonie Ulmke, Linh Pham, Hoang Duy Nguyen, Beate Brand-Saberi, Jochen F. Staiger, Andre Fischer, Huu Phuc Nguyen, Tran Tuoc   +9 more
doaj   +1 more source

Molecular mechanism of METTL14-mediated m6A modification regulating microglial function post ischemic stroke

Brain Research Bulletin
This study explores the molecular mechanism of METTL14 regulating microglial function post ischemic stroke. A murine model was established by tMCAO. The neurological function was evaluated by mNSS.
Xiaomin Zhang, Pengyang Du, Bo Bai, Xia Lian, Guofang Xue   +4 more
doaj   +1 more source

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

Investigative Ophthalmology & Visual Science
Limbal stem/progenitor cells (LSCs) continuously proliferate and differentiate to replenish the corneal epithelium and play a vital role in corneal function and normal vision. A previous study revealed that paired box 6 (PAX6) is a master transcription factor involved in determining the fate of corneal epithelial cells (CECs).
Zhu, Liqiong, Chen, Chaoqun, Wu, Siqi, Guo, Huizhen, Li, Lingyu, Wang, Li, Liu, Dongmei, Zhan, Yu, Du, Xinyue, Liu, Jiafeng, Tan, Jieying, Huang, Ying, Mo, Kunlun, Lan, Xihong, Ouyang, Hong, Yuan, Jin, Chen, Xiangjun, Ji, Jianping   +17 more
openaire   +2 more sources

PAX6 wt Allele [PDF]

, 2020
openaire   +1 more source

Kongenitale Aniridie oder PAX6-Syndrom? [PDF]

Der Ophthalmologe, 2014
B. Käsmann-Kellner, B. Seitz
openaire   +1 more source

Cooperation of Transcription Factor PAX6 with Chromatin-Remodeling Complex BAF During Embryonic Development in Mammals. [PDF]

Cell Mol Neurobiol
Azieva A, Vasilyeva T, Maksimenko O, Davydenko K, Zinchenko R, Marakhonov A.   +5 more
europepmc   +1 more source

Cartwheel cataract, a specific sign of PAX6 -related aniridia. [PDF]

J Cataract Refract Surg
Bremond-Gignac D, Daruich A, Valleix S, Robert MP.   +3 more
europepmc   +1 more source

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network. [PDF]

Nat Commun
Walth-Hummel AA, Jouffe C, Weber P, Motzler K, Geppert J, Sterr M, Gan W, Szczerbinska I, König AC, Hauck SM, Terron-Exposito R, Hass D, Wang C, Dyar KA, Lyon JG, Lickert H, Ämmälä C, Herzig S, Ashcroft FM, Bakhti M, MacDonald PE, Rohm M.   +21 more
europepmc   +1 more source