Results 111 to 120 of about 36,753 (224)
Scientific ReportsThe paired box 6 (Pax6) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands. Homozygous loss of Pax6 resulted in neonatal death in mice, plus loss of eyes and malformation of cerebral ...
Bichao Zhang +5 more
doaj +1 more source
A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies [PDF]
, 2019 Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments.
Cairns, Nigel J +7 more
core +1 more source
Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome
Journal of Neurochemistry, Volume 170, Issue 5, May 2026.Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins +9 more
wiley +1 more source
Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.
PLoS ONE, 2015 The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural development in the cerebral cortex and spinal cord, and to control pancreatic endocrine cell genesis.
Zeeshan Ahmad +3 more
doaj +1 more source
The last common bilaterian ancestor [PDF]
, 2002 Many regulatory genes appear to be utilized in at least superficially similar ways in the development of particular body parts in Drosophila and in chordates.
Davidson, Eric H., Erwin, Douglas H.
core
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.In the non‐diabetic beta‐cell (top left) activation of glucokinase (bottom left) leads to inhibition of mitochondrial metabolism and thereby impairs insulin secretion. The effect is similar to that of chronic hyperglycaemia as seen in the diabetic beta‐cell (top right).
Matthew Lloyd +9 more
wiley +1 more source
PLoS ONE, 2013 We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice.
Panagiotis Douvaras +7 more
doaj +1 more source
A rare case of congenital aniridia with an unusual run-on mutation in PAX6 gene
Indian Journal of Ophthalmology, 2022 Ria Ratna +5 more
doaj +1 more source
Take Pax6 for a Cortical 6-Pack
PLOS Biology, 2015 This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.
openaire +4 more sources
Requirements for Human Cerebral Organoids
Cell Proliferation, Volume 59, Issue 5, May 2026.
Ya‐Jie Xu +44 more
wiley +1 more source