Results 91 to 100 of about 21,466 (185)

Expression and interaction mechanism of PAX6 in human non-small cell lung cancer

Zhongguo aizheng zazhi, 2014
Background and purpose: The transcription factor PAX6 is primarily expressed in embryos. PAX6 is also expressed in several tumors and plays oncogenic or tumor suppressor role. This study aimed to investigate the expression of PAX 6 in non-small cell lung
熊安洲, 陈菁, 曹艳, 胡小萍
doaj  

Pax6-dependent mechanisms in mammalian corticogenesis

, 2007
Pax6 is a key transcription factor involved in the organogenesis of the eye, pancreas, and brain. In developing cortex, Pax6 has been implicated to play a role in regionalization, neurogenesis, layer formation, and axonal path finding. The study of whether Pax6 regulates key processes in corticogenesis and brain functioning has been hindered by a ...
openaire   +3 more sources

PAX6 aniridia and interhemispheric brain anomalies.

Molecular vision, 2009
To report the clinical and genetic study of patients with autosomal dominant aniridia.We studied ten patients with aniridia from three families of Egyptian origin. All patients underwent full ophthalmologic, general and neurological examination, and blood drawing.
Abouzeid, Hana, Youssef, Mohamed A., ElShakankiri, Nihal, Hauser, Philippe, Munier, Francis L., Schorderet, Daniel F.   +5 more
openaire   +3 more sources

H3 Acetylation-Induced Basal Progenitor Generation and Neocortex Expansion Depends on the Transcription Factor Pax6

Biology
Enrichment of basal progenitors (BPs) in the developing neocortex is a central driver of cortical enlargement. The transcription factor Pax6 is known as an essential regulator in generation of BPs.
Godwin Sokpor, Cemil Kerimoglu, Pauline Antonie Ulmke, Linh Pham, Hoang Duy Nguyen, Beate Brand-Saberi, Jochen F. Staiger, Andre Fischer, Huu Phuc Nguyen, Tran Tuoc   +9 more
doaj   +1 more source

Molecular mechanism of METTL14-mediated m6A modification regulating microglial function post ischemic stroke

Brain Research Bulletin
This study explores the molecular mechanism of METTL14 regulating microglial function post ischemic stroke. A murine model was established by tMCAO. The neurological function was evaluated by mNSS.
Xiaomin Zhang, Pengyang Du, Bo Bai, Xia Lian, Guofang Xue   +4 more
doaj   +1 more source

Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro.

PLoS ONE
PurposeIn the present study, we evaluate gene and protein expression levels in an in vitro siRNA-mediated PAX6 knockdown limbal epithelial cell (LEC) model after RA treatment.
Shao-Lun Hsu, Tanja Stachon, Fabian N Fries, Zhen Li, Shuailin Li, Shanhe Liu, Berthold Seitz, Swarnali Kundu, Maryam Amini, Shweta Suiwal, Nóra Szentmáry   +10 more
doaj   +1 more source

Human-Mouse Chimerism for Organogenesis Without Neural or Germline Contributions. [PDF]

Int J Biol Sci
Ye S, Kadier K, Yi Y, Qin G, Huang B, Fu S, Alev C, Xu RH.   +7 more
europepmc   +1 more source

Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/G3BP1 Axis. [PDF]

Clin Exp Pharmacol Physiol
Li K, Li M, Pan X, Xu J, Jiang R.
europepmc   +1 more source

Hereditary Congenital Cataract With Spastic Paraplegia Associated With a Missense PAX6 Variant (p.Arg26Trp). [PDF]

Cureus
Miura S, Namiguchi K, Matsumoto S, Sun Y, Shibata H.   +4 more
europepmc   +1 more source

Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio. [PDF]

Mol Biol Evol
Laumer EM, Neu SM, Klementz BC, Panda P, Setton EVW, Sharma PP.   +5 more
europepmc   +1 more source