Results 71 to 80 of about 21,466 (185)
Mapping the Pax6 3’ untranslated region microRNA regulatory landscape
BMC Genomics, 2018 Background PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have
Bridget C. Ryan +6 more
doaj +1 more source
Journal of Anatomy, EarlyView.A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera +9 more
wiley +1 more source
Intestinal Tumorigenicity of Mice Carrying Hemizygous Pax6, Pax6Sey-4H
Experimental Animals, 2007 The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6(Sey-4H), which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are ...
NITTA, Yumiko +5 more
openaire +3 more sources
Photochemistry and Photobiology, EarlyView.The circadian clock and melatonin coordinate homeostasis in many animals, yet their influence on reproduction and neoblast proliferation has only been shown in triclads. This study demonstrates that the early‐branching catenulid Stenostomum virginianum contains photoreceptive refractile bodies, synthesizes endogenous melatonin, and that exogenous ...
Daniel L. Stanton +5 more
wiley +1 more source
HeliyonSmall cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types.
Xiao-Fang Guo +3 more
doaj +1 more source
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
Glia, Volume 74, Issue 11, November 2026.ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo +6 more
wiley +1 more source
Journal of Comparative Neurology, Volume 534, Issue 10, October 2026.The hagfish, a jawless early‐branching vertebrate, has very rudimentary eyes that are diminutive and oddly devoid of melanin pigment. Yet, the degenerate hagfish eye grows throughout life and expresses canonical genes of vertebrate retinal development. ABSTRACT Comparative morphology has revealed fascinating structural and organizational differences in
Sarah N. Bradshaw, William T. Allison
wiley +1 more source
Clinical EpigeneticsBackground The progression of liver cancer is a complicated process that involves genetic and epigenetic changes. Paired box 6 (PAX6) is a critical transcription factor for embryonic development. PAX6 is abnormally methylated in human cancer. The role of
Ching-Hua Yeh +6 more
doaj +1 more source
Human Cortical Neural Progenitor Cells
Cell Proliferation, EarlyView.
An‐Xin Wang +29 more
wiley +1 more source