Results 71 to 80 of about 22,874 (232)
Pαx6 expression in postmitotic neurons mediates the growth of axons in response to SFRP1.
PLoS ONE, 2012 During development, the mechanisms that specify neuronal subclasses are coupled to those that determine their axonal response to guidance cues. Pax6 is a homedomain transcription factor required for the specification of a variety of neural precursors ...
Alvaro Sebastián-Serrano +5 more
doaj +1 more source
PLoS ONE, 2013 The transcription factor Pax6 is a developmental regulator with a crucial role in development of the eye, brain, and olfactory system. Pax6 is also required for correct development of the endocrine pancreas and specification of hormone producing ...
Alan W Hart +4 more
doaj +1 more source
Acta Ophthalmologica, EarlyView.Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry +27 more
wiley +1 more source
Cell Proliferation, EarlyView.The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang +11 more
wiley +1 more source
Not for the eyes only: PAX6 and glucose metabolism [PDF]
Diabetologia, 2009 Paired box 6 (PAX6) is a member of the PAX multigene family of transcription factors: this family regulates embryonic differentiation. Nine unlinked PAX genes dispersed throughout the genome encode proteins that each include a 128-amino-acid sequence-specific highly conserved DNA-binding domain, the Paired box, which can regulate the expression of ...
openaire +2 more sources
FMNL2 with functions related to the cytoskeleton is partially regulated by PAX6
Journal of Ophthalmic & Vision Research, 2017 Purpose: We aimed to assess whether the transcription factor PAX6 affects transcription of FMNL2. PAX6 is a transcription factor with significant roles in development of the eye and eye-related functions.
Elham Ghorbanpour +4 more
doaj +1 more source
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source
Intestinal Tumorigenicity of Mice Carrying Hemizygous Pax6, Pax6Sey-4H
Experimental Animals, 2007 The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6(Sey-4H), which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are ...
NITTA, Yumiko +5 more
openaire +3 more sources
Low-Dose Radiation Disrupts the Transcription Cascade of PAX6 [PDF]
, 2021 Mari Katsura +14 more
openalex +1 more source
Inflammatory Cytokines Impair Glucagon Expression and Secretion in Pancreatic α‐Cells
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Insulin resistance and obesity‐associated inflammation are key drivers in the pathogenesis of Type 2 diabetes mellitus (T2DM). Whilst inflammatory cytokines are well known to impair β‐cell function, their impact on pancreatic α‐cells and glucagon (GCG) regulation remains poorly understood. In this study, we investigated the effects of the
Caroline Bickelmann +5 more
wiley +1 more source