Results 81 to 90 of about 21,466 (185)

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, Volume 41, Issue 10, Page 906-921, October 2026.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

PAX6 Downregulation Triggers HIF-1α-Mediated Ferroptosis in Glioma Cells

Biomolecules
Background: The paired-box gene 6 (PAX6) is an important transcription factor in the central nervous system, mainly regulating the development and differentiation of embryonic eyes and the nervous system.
Qizhi Luo, Li Fu, Jie Zhang, Shashuang Zhang, Lixiang Wu, Quan Zhu, Baisheng Huang   +6 more
doaj   +1 more source

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.

PLoS ONE, 2015
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural development in the cerebral cortex and spinal cord, and to control pancreatic endocrine cell genesis.
Zeeshan Ahmad, Maria Rafeeq, Patrick Collombat, Ahmed Mansouri   +3 more
doaj   +1 more source

A rare case of congenital aniridia with an unusual run-on mutation in PAX6 gene

Indian Journal of Ophthalmology, 2022
Ria Ratna, Shailja Tibrewal, Abha Gour, Reena Gupta, Umang Mathur, Vanita Vanita   +5 more
doaj   +1 more source

Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia.

PLoS ONE, 2013
We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice.
Panagiotis Douvaras, Richard L Mort, Dominic Edwards, Kanna Ramaesh, Baljean Dhillon, Steven D Morley, Robert E Hill, John D West   +7 more
doaj   +1 more source

Take Pax6 for a Cortical 6-Pack

PLOS Biology, 2015
This synopsis examines the implications of a new study that imposes primate-like expression of the transcription factor Pax6 on the developing mouse cortex and finds evidence of primate-like proliferation of neuronal progenitors.
openaire   +4 more sources

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.

PLoS Genetics, 2009
Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell proliferation,
Stephen N Sansom, Dean S Griffiths, Andrea Faedo, Dirk-Jan Kleinjan, Youlin Ruan, James Smith, Veronica van Heyningen, John L Rubenstein, Frederick J Livesey   +8 more
doaj   +1 more source

Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer

Respiratory Research, 2018
Background This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was employed to detect SMAD3 expression in cancer tissues along with normal tissues ...
Zhe Qian, Qiankun Zhang, Ying Hu, Tongmei Zhang, Jie Li, Zan Liu, Hua Zheng, Yuan Gao, Wenyun Jia, Aimin Hu, Baolan Li, Jiqing Hao   +11 more
doaj   +1 more source

PAX6 (paired box 6) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PAX6 (paired box 6), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development

Scientific Reports
The paired box 6 (Pax6) gene encodes a highly conserved transcription factor, involved in the development of eyes, brain, and endocrine glands. Homozygous loss of Pax6 resulted in neonatal death in mice, plus loss of eyes and malformation of cerebral ...
Bichao Zhang, Meihua Hou, Jiayan Huang, Yunfei Liu, Ciqing Yang, Juntang Lin   +5 more
doaj   +1 more source