Results 41 to 50 of about 20,380 (169)

Effect of Pulsed Low-Level Lasers on Adult versus Neonatal Human Retinal Pigment Epithelial Cells: An in-vitro Study

Journal of Ophthalmic & Vision Research
Purpose: To investigate the short-term effects of low-level lasers (LLLs; also known as low-power laser therapy) on the structure, genetic, and phenotype of cultured human retinal pigment epithelial (hRPE) cells from both adult and neonatal sources ...
Seyed Mohamadmehdi Moshtaghion, Mohammad Abolhosseini, Faraj Tabeie, Sahar Balagholi, Fatemeh Suri, Samira Karami, Houra Naraghi, Mozhgan Rezaei Kanavi, Somayeh Asadi   +8 more
doaj   +1 more source

Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites.

PLoS ONE, 2014
Eye phenotypes were investigated in Le-Cre(Tg/-); Pax6(fl/+) mice, which were expected to show tissue-specific reduction of Pax6 in surface ectoderm derivatives.
Natalie J Dorà, J Martin Collinson, Robert E Hill, John D West   +3 more
doaj   +1 more source

Novel lines of Pax6^-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability

BMC Neuroscience, 2010
Background Embryonic stem (ES) cells can differentiate into all cell types and have been used extensively to study factors affecting neuronal differentiation.
Nowakowski Tomasz J, Molinek Michael, Quinn Jane C, Mason John O, Price David J   +4 more
doaj   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Blood Serum From Obese Women Raises ROS Production by Neural Stem Cells [PDF]

Dev Neurobiol
ABSTRACT Maternal obesity has been associated with adverse pregnancy outcomes and altered fetal development, but the direct influence of circulating maternal factors on early human neural cells remains poorly understood. Neural stem cells (NSCs) provide a controlled system to examine how metabolic and inflammatory changes may affect early ...
da Silva P, Corrêa N, Silva N, Ueira‐Vieira C, Almeida‐Souza H, Martins M, Silva T, Zanon R.   +7 more
europepmc   +2 more sources

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Protecting Pax6 3′ UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model

Molecular Therapy: Nucleic Acids, 2018
Aniridia is a rare congenital syndrome that is associated with reduced visual acuity and progressive loss of vision. Aniridia patients may also develop systemic health issues associated with defects in the pancreas, digestive, and central nervous systems.
Kevin Yongblah, Spencer C. Alford, Bridget C. Ryan, Robert L. Chow, Perry L. Howard   +4 more
doaj   +1 more source

Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2‐Hippo signaling pathway

Clinical and Translational Medicine, 2021
Intrinsic resistance to CDK4/6 inhibitors hinders their clinical utility in cancer treatment. Furthermore, the predictive markers of CDK4/6 inhibitors in gastric cancer (GC) remain incompletely described.
Yi Zhang, Long‐Jun He, Lin‐Lin Huang, Sheng Yao, Nan Lin, Ping Li, Hui‐Wen Xu, Xi‐Wen Wu, Jian‐Liang Xu, Yi Lu, Yan‐Jie Li, Sen‐Lin Zhu   +11 more
doaj   +1 more source