Results 61 to 70 of about 20,380 (169)
Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci
Cell Proliferation, EarlyView.To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
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Cancer Management and Research, 2020 Xian Hu Zhang,1 Bing Feng Li,1 Jie Ding,2 Lei Shi,1 Huo Ming Ren,1 Kui Liu,1 Chuan Cai Huang,1 Fu Xiao Ma,1 Xin Yao Wu1 1Department of General Surgery, Suzhou First People’s Hospital, Suzhou, Anhui 234000, People’s Republic of China ...
Zhang XH +8 more
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BMC Genetics, 2005 Background The PAX6 protein is a transcriptional regulator with a key role in ocular and neurological development. Individuals with heterozygous loss-of-function mutations in the PAX6 gene have malformations of the eye and brain.
Hanson Isabel M, Cooper Simon T
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Histopathology, EarlyView.PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert +5 more
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FMNL2 with functions related to the cytoskeleton is partially regulated by PAX6
Journal of Ophthalmic & Vision Research, 2017 Purpose: We aimed to assess whether the transcription factor PAX6 affects transcription of FMNL2. PAX6 is a transcription factor with significant roles in development of the eye and eye-related functions.
Elham Ghorbanpour +4 more
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Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. [PDF]
PLoS ONE, 2013 Keratinizing squamous metaplasia (SQM) of the ocular surface is a blinding consequence of systemic autoimmune disease and there is no cure. Ocular SQM is traditionally viewed as an adaptive tissue response during chronic keratoconjunctivitis sicca (KCS ...
Ying Ting Chen +5 more
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The Journal of Physiology, EarlyView.Abstract figure legend Maternal obesity (MO) creates a pro‐inflammatory embryonic environment, which activates the activator protein 1 (AP‐1) transcription factor complex, resulting in reduced expression of key neurogenic regulators and impaired neuronal differentiation.
Li‐Wei Chen +9 more
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PLoS Genetics, 2009 Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell proliferation,
Stephen N Sansom +8 more
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The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
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Pαx6 expression in postmitotic neurons mediates the growth of axons in response to SFRP1.
PLoS ONE, 2012 During development, the mechanisms that specify neuronal subclasses are coupled to those that determine their axonal response to guidance cues. Pax6 is a homedomain transcription factor required for the specification of a variety of neural precursors ...
Alvaro Sebastián-Serrano +5 more
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