Results 71 to 80 of about 20,380 (169)

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells

Heliyon
Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types.
Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li   +3 more
doaj   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. ABSTRACT Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors

BMC Neuroscience, 2017
Background We studied whether regulation of Cdca7 (Cell division cycle associated 7) expression by transcription factor Pax6 contributes to Pax6’s cellular actions during corticogenesis.
Yu-Ting Huang, John O. Mason, David J. Price   +2 more
doaj   +1 more source

Peters Anomaly in a Miniature Schnauzer Documented by Spectral‐Domain Optical Coherence Tomography: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT A 10‐month‐old intact male Miniature Schnauzer was presented for evaluation of a unilateral corneal opacity in the right eye. Ophthalmic examination revealed a broad paraxial corneal opacity involving the posterior stroma to the Descemet's membrane, with multiple strands of tissue extending from the iris collarette to the posterior cornea ...
Yukihiro Miwa, Deokho Lee, Yuri Inukai
wiley   +1 more source

Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer

Respiratory Research, 2018
Background This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was employed to detect SMAD3 expression in cancer tissues along with normal tissues ...
Zhe Qian, Qiankun Zhang, Ying Hu, Tongmei Zhang, Jie Li, Zan Liu, Hua Zheng, Yuan Gao, Wenyun Jia, Aimin Hu, Baolan Li, Jiqing Hao   +11 more
doaj   +1 more source

Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes

Glia, Volume 74, Issue 3, March 2026.
ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve, Mariana Bresque, Daniel Okhuevbie, Sandhya Ramachandran, Mariana Pehar, Marcelo R. Vargas   +5 more
wiley   +1 more source

Promoter hypermethylation-mediated downregulation of PAX6 promotes tumor growth and metastasis during the progression of liver cancer

Clinical Epigenetics
Background The progression of liver cancer is a complicated process that involves genetic and epigenetic changes. Paired box 6 (PAX6) is a critical transcription factor for embryonic development. PAX6 is abnormally methylated in human cancer. The role of
Ching-Hua Yeh, Rou-Yu Chen, Ti-Hui Wu, Shan-Yueh Chang, Tsai-Yuan Hsieh, Yu-Lueng Shih, Ya-Wen Lin   +6 more
doaj   +1 more source

Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium

Genes to Cells, Volume 31, Issue 2, March 2026.
Foxg1 maintains neurogenic progenitor potential in the ventrolateral olfactory epithelium. In control (Foxg1‐cHET) embryos, Foxg1‐expressing progenitors preferentially generate olfactory sensory neurons (OSNs) and support V‐zone expansion. Conditional Foxg1 deletion (Foxg1‐cKO) reduces V‐zone growth and shifts progenitor fate toward sustentacular cells
Anzu Kuriyama, Yuta Furusho, Carina Hanashima   +2 more
wiley   +1 more source

Mapping the Pax6 3’ untranslated region microRNA regulatory landscape

BMC Genomics, 2018
Background PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have
Bridget C. Ryan, Kieran Lowe, Laura Hanson, Talveen Gil, Lauren Braun, Perry L. Howard, Robert L. Chow   +6 more
doaj   +1 more source