Results 181 to 190 of about 2,757 (201)
Thymopoiesis requiresPax9 function in thymic epithelial cells [PDF]
European Journal of Immunology, 2002 peer reviewedThe epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches.
Michael Schorpp +2 more
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Non-syndromic Oligodontia with a Novel Mutation of PAX9
Journal of Dental Research, 2010Agenesis of the permanent teeth is a congenital anomaly that is frequently seen in humans. Oligodontia is a severe type of tooth agenesis involving 6 or more congenitally missing teeth, excluding the third molars. Previous studies have indicated that mutations in the homeobox gene MSX1, paired domain transcription factor PAX9, and EDA are associated ...
N, Suda +4 more
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A Novel Mutation in Human PAX9 Causes Molar Oligodontia
Journal of Dental Research, 2002Experimental and animal studies, as well as genetic mutations in man, have indicated that the development of dentition is under the control of several genes. So far, mutations in MSX1 and PAX9 have been associated with dominantly inherited forms of human tooth agenesis that mainly involve posterior teeth.
S A, Frazier-Bowers +7 more
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Su1166 Pax9 is Critical for Esophageal Epithelial Development
Gastroenterology, 2012Background and Aims: Autophagy is a normal physiological mechanism for the degradation of cellular proteins and organelles. Excessive autophagy induced by cellular stress leads to cell death. However, the exact role of autophagy in cancer is not completely clear. Beclin1 plays a central role in the regulation of autophagy.
Hao Chen +4 more
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Paired box 9 (PAX9) is one of the best‐known transcription factors involved in the development of human dentition. Mutations in PAX9 gene could, therefore, seriously influence the number, position and morphology of the teeth in an affected individual. To date, over 50 mutations in the gene have been reported as associated with various types of dental ...
O. Bonczek, V.J. Balcar, O. Šerý
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The Function and Regulatory Network of Pax9 Gene in Palate Development
Journal of Dental Research, 2018Cleft palate, a common congenital deformity, can arise from disruptions in any stage of palatogenesis, including palatal shelf growth, elevation, adhesion, and fusion. Paired box gene 9 (Pax9) is recognized as a vital regulator of palatogenesis with great relevance to cleft palate in humans and mice.
R. Li, Z. Chen, Q. Yu, M. Weng, Z. Chen
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The dominant negative mutation of PAX9 in nonsyndromic tooth agenesis
Clinical Oral InvestigationsPaired box 9 (PAX9) is a transcription factor that plays a critical role in the development of human dentition. Although various mutations in the PAX9 gene have been identified to date, the mechanisms by which these mutations cause non-syndromic tooth agenesis (NSTA) remain not fully understood.
Yuhua, Pan +7 more
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Pax9 drives development of the upper jaw but not teeth in zebrafish
Developmental BiologyLoss of dentition has occurred repeatedly throughout vertebrate evolution. Cyprinid fish, including zebrafish, form teeth only deep within the pharynx, not on their oral jaws. However, zebrafish still robustly express transcription factors associated with mammalian tooth development in the neural crest-derived mesenchyme surrounding the mouth.
Sandhya Paudel +3 more
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Alcohol drinking inhibits NOTCH–PAX9 signaling in esophageal squamous epithelial cells
Journal of Pathology, 2021Menghan Shi, Zheng Sun, Xiaoxin Chen
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