Results 61 to 70 of about 4,535 (170)

Association between Paxlovid and mortality in severe COVID-19 patients: a retrospective cohort study

Journal of Infection in Developing Countries
Introduction: With limited research on the clinical effectiveness of Paxlovid for hospitalized patients with severe COVID-19, this study aims to assess its impact on clinical outcomes, providing essential insights for patient care.
Bin Liu, Bo Xie, Li Jiang, Hongli Xia, Chunmei Zhu, Jing Hu, Jing Cai, Yan Zhang, Mingjin Yang, Yanchao Liang   +9 more
doaj   +1 more source

Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça, Donald Seanego, Christopher Jurisch, Melina Mottin, Flávia Nader Motta, Beatriz S. A. Rodrigues, Gilberto S. M. Junior, Alexandra Maria dos Santos Carvalho, Fábio Muniz de Oliveira, Sunniva Sigurdardóttir, Per Sunnerhagen, Izabela Marques Dourado Bastos, Richard Gessner, Kelly Chibale, Carolina Horta Andrade   +14 more
wiley   +1 more source

Paxlovid: A Regulatory Gamble

The American Journal of Medicine, 2023
Miloš D. Miljković, Vinay Prasad
openaire   +4 more sources

COVID‐19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross‐Sectional Survey of Cohort Participants

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Despite evidence of effectiveness, oral antivirals for COVID‐19 are underused, with significant variation across populations. This study examines COVID‐19 treatment awareness, knowledge, access, trusted sources, and willingness to use among diverse essential workers in Tennessee during May 18, 2023–June 1, 2024.
Jenae Sanders, Jade James‐Gist, Melisa M. Shah, Nathan Graff, Olivia Almendares, Tiffany Israel, Yuwei Zhu, Bryan Blette, Sarah Hamid, Hope King, H. Keipp Talbot, Carlos G. Grijalva, Melissa Briggs‐Hagen   +12 more
wiley   +1 more source

A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years

Acta Pharmaceutica Sinica B
Azvudine and nirmatrelvir/ritonavir (Paxlovid) are recommended for COVID-19 treatment in China, but their safety and efficacy in the elderly population are not fully known.
Bo Yu, Haiyu Wang, Guangming Li, Junyi Sun, Hong Luo, Mengzhao Yang, Yanyang Zhang, Ruihan Liu, Ming Cheng, Shixi Zhang, Guotao Li, Ling Wang, Guowu Qian, Donghua Zhang, Silin Li, Quancheng Kan, Jiandong Jiang, Zhigang Ren   +17 more
doaj   +1 more source

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus serve as a prophylactic agent.
Vanyo Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tachkov, Violeta Dimitrova   +4 more
wiley   +1 more source

Native American Pregnant and Postpartum People's Experiences of Discrimination During Perinatal Care: A Qualitative Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 5, Page 1026-1036, April 2026.
ABSTRACT Objective Indigenous pregnant and postpartum people are more likely to experience severe maternal morbidity (SMM) and mortality than non‐Indigenous groups. We sought to explore how community and societal factors, culture, and resilience impact Native American individuals' pregnancy experiences and might offer insights to address inequities in ...
Jennifer L. Murray, Heather Tanana, Torri D. Metz, Reham Perry, Elisabeth R. Kimball, Patrick Galyean, Susan Zickmund, Michael W. Varner, Michelle P. Debbink   +8 more
wiley   +1 more source

Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Pregnant Women Treated with Nirmatrelvir/Ritonavir (Paxlovid) Using Salivary Polymerase Chain Reaction: A Prospective Cohort Study

Microorganisms
Objectives: We aim to study the relative viral load using salivary polymerase chain reaction among pregnant women treated with Paxlovid. Methods: Pregnant women with coronavirus disease 2019 were allocated to two groups: those receiving Paxlovid and ...
Chun-Han Tseng, Chih-Wei Lin, Pei-Yin Tsai, Mei-Tsz Su   +3 more
doaj   +1 more source

Navigating the COVID-19 Therapeutic Landscape: Unveiling Novel Perspectives on FDA-Approved Medications, Vaccination Targets, and Emerging Novel Strategies

Molecules
Amidst the ongoing global challenge of the SARS-CoV-2 pandemic, the quest for effective antiviral medications remains paramount. This comprehensive review delves into the dynamic landscape of FDA-approved medications repurposed for COVID-19, categorized ...
Reham F. Barghash, Donato Gemmati, Ahmed M. Awad, Mustafa M. M. Elbakry, Veronica Tisato, Kareem Awad, Ajay Vikram Singh   +6 more
doaj   +1 more source

Paxlovid in Kidney Failure: A Review

MPI (Media Pharmaceutica Indonesiana)
The COVID-19 virus caused a global pandemic that claimed many lives. Various vaccines and drugs are used for COVID-19 both via intravenous and oral routes. Paxlovid is a treatment given orally to patients who experience symptoms and is even considered effective in reducing high-risk COVID-19 virus infections.
Nonie Ardianty, null Suharjono, Didik Hasmono   +2 more
openaire   +1 more source