Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Energy dependence of multiplicity fluctuations in heavy ion collisions [PDF]
The energy dependence of multiplicity fluctuations was studied for the most central Pb+Pb collisions at 20A, 30A, 40A, 80A and 158A GeV by the NA49 experiment at the CERN SPS. The multiplicity distribution for negatively and positively charged hadrons is
Vassiliou, Maria +99 more
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Pb-isotope ratios and the petrogenesis of the Tunkillia Suite, Gawler Craton
In situ Pb-isotope ratios of alkali feldspars from laser ablation ICP-MS (LA-ICP-MS) were used to constrain melt-sources of the ca 1690–1670 Ma Tunkillia Suite, an important suite of intrusive rocks located in the Archean–Mesoproterozoic Gawler Craton ...
Sebastien Meffre (14744152) +3 more
core
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Pb-Sb spine and pasted positive plates used in lead acid batteries produced by casting methods.
Pb-Sb spine and pasted positive plates used in lead acid batteries produced by casting methods.
El-Sayed M. Sherif (1831849) +5 more
core +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
U-Pb geochronology of the Fort Augustus granite gneiss: constraints on the timing of Neoproterozoic and Palaeozoic tectonothermal events in the NW Highlands of Scotland [PDF]
The West Highland granite gneiss suite in Inverness-shire, Scotland, represents a series of S-type, anatectic granites formed by partial melting of host Neoproterozoic metasediments of the Moine Supergroup.
Kinny, P.D. +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Azimuthal anisotropy in Pb+Pb, Xe+Xe and p+Pb collisions and vn–pt correlations in Pb+Pb and p+Pb collisions with the ATLAS experiment [PDF]
openaire +1 more source

