Results 151 to 160 of about 849,713 (290)

PEMANFAATAN PUPUK HAYATI UNTUK BIOREMEDIASI TIMBAL (Pb) PADA TANAMAN APU-APU (Pistia stratiotes L.)

JTSL (Jurnal Tanah dan Sumberdaya Lahan)
Water pollution by heavy metals such as lead (Pb) causes toxic effects that inhibit the growth of aquatic organisms. Bioremediation using microorganisms such as Azotobacter sp. and Pseudomonas sp.
Fanny Maharani Putri, Vera Oktavia Subardja, Bastaman Syah   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

O não preenchimento do objeto anafórico na língua portuguesa: análise diacrônica do PB e do PE dos séculos XIX e XX [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Linguística, Florianópolis, 2011Esta pesquisa trata da investigação diacrônica em torno da (não)realização do objeto anafórico na ...
Costa, Sueli
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Indications for the onset of deconfinement in Pb + Pb collisions at the CERN SPS from NA49 [PDF]

, 2005
Particle production in central Pb+Pb collisions was studied with the NA49 large acceptance spectrometer at the CERN SPS at beam energies of 20, 30, 40, 80, and 158 GeV per nucleon.
Vassiliou, Maria, Molnar, József, Litov, Leandr, Panayotov, Dobromir, Boimska, Bożena, Darmenov, Nikolay, Friese, Volker, Markert, Christina, Kadija, Krešo, Pálla, Gabriella, Mayes, Bill W., Sitar, Branislav, Botje, Michiel, Stefanek, Grzegorz, Lungwitz, Benjamin, Foka, Panagiota, Trainor, Thomas A., Pinsky, Lawrence, Sann, Hans, Bramm, Roland, Mischke, André, Richard, Agnes Carol Joanna, Roland, Gunther, Kowalski, Marek, Białkowska, Helena, Dinkelaker, Peter, Wetzler, Alexander Albert, Blume, Christoph, Cramer, John G., Hoehne, Claudia, Veres, Gábor I., Szentpetery, Imre, Betev, Latchezar, Sandoval, Andres, Christakoglou, Panagiotis, Chvala, Ondrej, Włodarczyk, Zbigniew, Malakhov, Aleksandr I., Roland, Christof, Schmitz, Norbert, Barna, Daniel, Grebieszkow, Katarzyna, Dimitrov, Anton, Černý, Vladimír, Leeuwen, Marco van, Karev, Alexandre, Meurer, Christine, Farantatos, Gerassimos, Rybicki, Andrzej, Vranić, Danilo, Kolesnikov, Vadim I., Yoo, In-Kwon, Skrzypczak, Ewa, Mateev, Matej D., Seyboth, Peter, Sziklai, János, Bracinik, Juraj, Mitrovski, Michael Kosta, Kraus, Ingrid, Varga, Dezsö, Kniege, Stefan, Hegyi, Sándor, Gál, József, Georgopoulos, George, Panagiotou, Apostolos D., Kornaś, Ewelina, Csató, Péter, Kreps, Michal, Makariev, Martin Vasilev, Bartke, Jerzy, Brun, René, Eckardt, Volker, Rybczyński, Maciej, Sikler, Ferenc, Freund, Peter, Bunčić, Predrag, Zaranek, Jacek, Vesztergombi, György, Baatar, B., Melkumov, Georgy L., Stock, Reinhard, Gaździcki, Marek, Ströbele, Herbert, Antičić, Tome, Kliemant, Michael, Pikna, Miroslav, Fodor, Zoltán, Gładysz-Dziaduś, Ewa, Korus, Robert, Pühlhofer, Falk, Petridis, Athanasios, Renfordt, Rainer Arno Ernst, Kollegger, Thorsten, Mrowczynski, Stanislaw, Zimanyi, József, Alt, Christopher, Lévai, Péter, Flierl, Dominik Bernhard, Šuša, Tatjana   +98 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source