Results 171 to 180 of about 695,368 (295)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Production In Pb–Pb Collisions At Tev
, 2019 A measurement of the production of prompt ${\Lambda }_{c}^{+}$ baryons in Pb–Pb collisions at $\sqrt{{s}_{\mathrm{NN}}}=5.02$ TeV with the ALICE detector at the LHC is reported. The ${\Lambda }_{c}^{+}$ and ${{\stackrel{‾}{\Lambda }}_{c}}^{-}$ were reconstructed at midrapidity ($|y|<0.5$) via the hadronic decay channel ${\Lambda }_{c}^{+}\to p{K}_{S}
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
$\Upsilon$ production in p-Pb and Pb-Pb collisions with ALICE at the LHC
, 2016 ALICE (A Large Ion Collider Experiment) is devoted to the study of heavy-ion collisions at LHC energies. In such collisions a deconfined state of nuclear matter, the Quark-Gluon Plasma (QGP), is formed. Due to their early production, quarkonium states are good probes to study the QGP evolution.
openaire +2 more sources
Mitigation of lead stress in Zea mays L. plants: the role of Trichoderma harzianum Zag-1 in enhancing antioxidant defense and physiological stability. [PDF]
BMC Plant BiolTaha AS, Soliman SA, Metwally RA.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Soil Lead Risks Associated With Urbanization Histories in Springfield MA and Hartford CT, USA. [PDF]
GeohealthPerdrial N +4 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source