Results 151 to 160 of about 2,102,666 (322)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pacific Blue Derivatives of Paclitaxel as Fluorescent Probes of OATP1B-Type Transporters. [PDF]

Clin Transl Sci
Nepal MR, Xu Y, Jin Y, Hu P, Hu X, Rane DS, Andres AE, Ahmed EA, Steiger B, Sparreboom A, Peterson BR, Hu S.   +11 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Blood-Based Lead Biomarkers and Sarcopenia Indicators in Older Adults. [PDF]

J Cachexia Sarcopenia Muscle
Koni A, Santos-Cuerva A, Sotos-Prieto M, Ortolá R, Olmedo P, García-Pérez J, Ramis R, Carballo-Casla A, Gil F, González-Palacios J, Pastor-Barriuso R, Navas-Acién A, Plans-Beriso E, Fernández-Navarro P, Rodríguez-Artalejo F, García-Esquinas E.   +15 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A near-infrared Sn-Pb perovskite imager with monolithic integration. [PDF]

Light Sci Appl
Ge C, Deng C, Zhu J, Zhu Y, Xu Q, Jiang B, Chen L, Liu Y, Song B, Fu P, Chen C, Gao L, Tang J.   +12 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Highly Efficient Adsorption of Pb(II) by Magnesium-Modified Zeolite: Performance and Mechanisms. [PDF]

Toxics
Yang Y, Wang X, Abbasi SS, Zhou B, Huang Q, Zhang S, Xiao X, Li H, Chen H, Hu Y.   +9 more
europepmc   +1 more source

SIMS zircon U-Pb geochronology and Sr-Nd isotopes of Ni-Cu-Bearing Mafic-Ultramafic Intrusions in Eastern Tianshan and Beishan in correlation with flood basalts in Tarim Basin (NW China): Constraints on a ca. 280 Ma mantle plume [PDF]

, 2011
Kezhang Qin, Baopeng Su, Patrick Asamoah Sakyi, Dongmei Tang, X-J Li, Hai‐Jian Sun, Qi-Bing Xiao, Patricia Pingping Liu   +7 more
openalex   +1 more source