Results 201 to 210 of about 2,102,666 (322)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evolution Landscape of PiggyBac (PB) Transposon in Beetles (Coleoptera). [PDF]

Genes (Basel)
Wang Q, Shi S, Wang B, Chen X, Yang N, Gao B, Song C.   +6 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Material Properties, Characterization, and Application of Microcellular Injection-Molded Polypropylene Reinforced with Oyster Shells for Pb(II) Adsorption Kinetics from Aqueous Solutions. [PDF]

Polymers (Basel)
Chien M, Bunekar N, Donga C, Mbule P, Moja TN, Hwang S.   +5 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Metal Pollution in the Air and Its Effects on Vulnerable Populations: A Narrative Review. [PDF]

Int J Mol Sci
Gonzalez-Villalva A, Rojas-Lemus M, López-Valdez N, Cervantes-Valencia ME, Guerrero-Palomo G, Casarrubias-Tabarez B, Bizarro-Nevares P, Morales-Ricardes G, García-Peláez I, Ustarroz-Cano M, Salgado-Hernández JÁ, Reséndiz Ramírez P, Villafaña Guillén N, Cevallos L, Teniza M, Fortoul TI.   +15 more
europepmc   +1 more source

The management of basic sanitation in the city of Campina Grande – PB: a look at the years 2007 to 2020 [PDF]

Wilton Maia Velez
openalex  

Supplemental Material: Direct constraints on shale fluid overpressure evolution from U-Pb dating of bed-parallel fracture-filling calcite

Chen Zhang, et al.
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential. [PDF]

World J Exp Med
Singla N, Mittal P, Babu MA, V Menon S, Ray S, Ali H, Purohit M, Goyal K, Mishra R, Hussain MS, Rekha A, Gupta G.   +11 more
europepmc   +1 more source