Results 211 to 220 of about 1,967,577 (277)

Single stereocenter inversion of a cyclic tetrapeptide enables the detoxification of lead-exposed mice. [PDF]

Chem Sci
Mohammed TA, Sauser L, Pedron E, Hodel YA, Kalvoda T, Prisco F, Rulíšek L, Holland JP, Shoshan MS.   +8 more
europepmc   +1 more source

Pb‒Pb dating of Yamato 86032

Pb‒Pb dating of Yamato 86032
The 13th Symposium on Polar Science/Ordinary sessions [OA] Antarctic meteorites, Thu. 17 Nov.
openaire  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Atmospheric Dry and Lead Deposition in an Arid Mexican City: Legacy of Smelting and Leaded Gasoline. [PDF]

Arch Environ Contam Toxicol
Soto-Jiménez MF, Zhao S, Jaffer E, Jocobi-Aguilar CL.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prussian blue-supported platinum nanoparticles as pH-Universal catalase mimics: enabling robust chemiluminescent immunoassay for VEGF in clinical diagnostics. [PDF]

Front Bioeng Biotechnol
Yang Y, Li J, Hu X, Xiu Y, Zhang M, Wang C, Liu X, Liang B, Xing D, Zhang T.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Epidemiology, clinical characteristics, and risk factors of plastic bronchitis caused by severe Mycoplasma pneumoniae pneumonia in children: a retrospective study from Suzhou, China. [PDF]

Front Pediatr
Ping L, Xu X, Zhang X, Yang X, Wang Y, Zhang J, Zhang H, Hao C.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Yeast prebiotics mitigate lead toxicity in Nile tilapia through physiological and ultrastructural improvements. [PDF]

Sci Rep
El-Fahla NA, Dessouki AA, Mohallal ME, Gad El-Hak HN, Yusuf MS, Abdelrazek HMA, Elrayess RA.   +6 more
europepmc   +1 more source