Results 61 to 70 of about 133 (76)
Some of the next articles are maybe not open access.
Journal of Clinical Oncology, 2020
698 Background: Survival statistics for mPDA are dismal and with limited treatment options novel agents are needed to improve disease outcomes. PBI-05204 (Phoenix Biotechnology, Inc., San Antonio, TX) is a modified supercritical carbon dioxide extract of Nerium oleander leaves. Oleandrin, the extract’s major cytotoxic component, has demonstrated anti-
Marc Thomas Roth +8 more
openaire +1 more source
698 Background: Survival statistics for mPDA are dismal and with limited treatment options novel agents are needed to improve disease outcomes. PBI-05204 (Phoenix Biotechnology, Inc., San Antonio, TX) is a modified supercritical carbon dioxide extract of Nerium oleander leaves. Oleandrin, the extract’s major cytotoxic component, has demonstrated anti-
Marc Thomas Roth +8 more
openaire +1 more source
Cancer Research, 2022
Abstract Glioblastoma multiforme (GBM) is an aggressive form of primary brain neoplasm that has a poor prognosis and is resistant to conventional treatment. There is a great need to develop new strategies to improve the outcome of this disease.
Sharmistha Chakraborty +2 more
openaire +1 more source
Abstract Glioblastoma multiforme (GBM) is an aggressive form of primary brain neoplasm that has a poor prognosis and is resistant to conventional treatment. There is a great need to develop new strategies to improve the outcome of this disease.
Sharmistha Chakraborty +2 more
openaire +1 more source
Journal of Clinical Oncology, 2009
3537 Background: PBI-05204 contains oleandrin, a cardiac glycoside, which inhibits the α-3 subunit Na-K ATPase pump. Over-expression of the α-3 subunit in malignant cells correlates with the tumor proliferation. Oleandrin inhibits FGF- 2 export and activation of NF-Kβ and inhibits phosphorylation of Akt.
S. Bidyasar +10 more
openaire +1 more source
3537 Background: PBI-05204 contains oleandrin, a cardiac glycoside, which inhibits the α-3 subunit Na-K ATPase pump. Over-expression of the α-3 subunit in malignant cells correlates with the tumor proliferation. Oleandrin inhibits FGF- 2 export and activation of NF-Kβ and inhibits phosphorylation of Akt.
S. Bidyasar +10 more
openaire +1 more source
Journal of Clinical Oncology, 2011
3023 Background: PBI-05204 (Oleandrin), a cardiac glycoside, inhibits the α-3 subunit Na-K ATPase pump. Relative expression of the α-3 subunit in tumor cells correlates with proliferation. Oleandrin inhibits FGF-2 export, activation of NF-Kβ, phosphorylation of Akt, p70S6K, decreasing mTOR activity.
H. A. Henary +13 more
openaire +1 more source
3023 Background: PBI-05204 (Oleandrin), a cardiac glycoside, inhibits the α-3 subunit Na-K ATPase pump. Relative expression of the α-3 subunit in tumor cells correlates with proliferation. Oleandrin inhibits FGF-2 export, activation of NF-Kβ, phosphorylation of Akt, p70S6K, decreasing mTOR activity.
H. A. Henary +13 more
openaire +1 more source
Cancer Research, 2013
Abstract Recent studies have suggested that cardiac glycosides (CGs), such as oleandrin, have an ability to inhibit the proliferation of various cancer cells, including those from pancreatic, non-small cell lung cancer, prostate, colon and breast cancers.
Yong Pan +8 more
openaire +1 more source
Abstract Recent studies have suggested that cardiac glycosides (CGs), such as oleandrin, have an ability to inhibit the proliferation of various cancer cells, including those from pancreatic, non-small cell lung cancer, prostate, colon and breast cancers.
Yong Pan +8 more
openaire +1 more source
Investigational new drugs, 2016
Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI-05204, a supercritical C0₂ extract of Nerium oleander containing oleandrin, in a human pancreatic cancer Panc-1 orthotopic model.
Yong, Pan +11 more
openaire +1 more source
Introduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI-05204, a supercritical C0₂ extract of Nerium oleander containing oleandrin, in a human pancreatic cancer Panc-1 orthotopic model.
Yong, Pan +11 more
openaire +1 more source