Results 1 to 10 of about 873 (179)
Case Report: Oleandrin intoxication by inhalation in beef cattle [PDF]
Frontiers in Veterinary ScienceOleander (Nerium oleander) contains more than 30 different toxic cardiac glycosides, including oleandrin. Intoxication can occur through ingestion or inhalation in several species, including cattle.
Anastasia Lisuzzo +11 more
exaly +9 more sources
The effect of 5α-oleandrin on keloid fibroblast activities [PDF]
BMC Proceedings, 2019 Background Keloids develop due to hyperactivity of keloid fibroblast (KF) in proliferation, migration, and collagen deposition along with low rates of collagen degradation.
Ishandono Dachlan +5 more
doaj +5 more sources
Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions [PDF]
Molecules, 2023 The Nerium oleander extract PBI 05204 (PBI) and its cardiac glycoside constituent oleandrin have direct anti-viral properties. Their effect on the immune system, however, is largely unknown. We used an in vitro model of human peripheral blood mononuclear
Gitte S. Jensen +5 more
doaj +3 more sources
Function of inhibition of RNA virus replication by digoxin and oleandrin [PDF]
Xin yixue, 2023 Objective To evaluate the antiviral ability of cardiac glycosides of digoxin and oleandrin. Methods Human adenocarcinoma alveolar basal epithelial cell line （A549） and African green monkey kidney cell line （vero） were used for subsequent experiment.
Liao Xialin, Liang Wei, Chen Jiawen, Liu Kunpeng
doaj +3 more sources
Antiviral effects of oleandrin [PDF]
Journal of the American College of Emergency Physicians Open, 2021 More importantly, our published studies demonstrated the safety of the plant extract in the Food and Drug Administration (FDA)-approved Phase I and II clinical trials in cancer patients through the use of our novel drug PBI-05204. [...]that is our current aim for PBI-05204.
R. Newman, K. Jagannadha Sastry
doaj +3 more sources
Frontiers in Pharmacology, 2022 Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander (Apocynaceae) and is used as a traditional herbal medicine due to its excellent pharmacological properties. It is widely applied for various disease treatments,
Xiaoru Dong
exaly +3 more sources
Antiviral Effects of Oleandrin
Journal of Experimental Pharmacology, 2020 Robert A Newman, 1, 2 K Jagannadha Sastry, 3 Ravit Arav-Boger, 4 Hongyi Cai, 5 Rick Matos, 6 Robert Harrod 7 1Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA; 2Phoenix Biotechnology,
Newman RA +5 more
doaj +3 more sources
Discovery of senolytics using machine learning [PDF]
Nature Communications, 2023 Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer-Barreto +10 more
doaj +2 more sources
Poisoning by Nerium oleander L. in Franconia Geese [PDF]
AnimalsThis study describes the acute poisoning of four 3-month-old Franconia geese (Anser anser) by oleander plants (Nerium oleander). After the accidental ingestion of oleander clippings, the geese exhibited a rapid onset of severe symptoms, leading to ...
Nicola Pugliese +12 more
doaj +2 more sources
Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]
Int J Mol Cell Med, 2023 Endometrial carcinoma is one of the most common types of cancer among women. The progression of cancer occurs via the Epithelial- Mesenchymal Transition (EMT) pathway. Cells lose their epithelial properties and become mobile. For this reason, the EMT process is one of the most important step to be targeted in cancer treatment.
Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc +3 more sources