Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology [PDF]
Frontiers in Pharmacology, 2022 Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander (Apocynaceae) and is used as a traditional herbal medicine due to its excellent pharmacological properties. It is widely applied for various disease treatments,
Xiaoru Dong +2 more
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Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions [PDF]
Molecules, 2023 The Nerium oleander extract PBI 05204 (PBI) and its cardiac glycoside constituent oleandrin have direct anti-viral properties. Their effect on the immune system, however, is largely unknown. We used an in vitro model of human peripheral blood mononuclear
Gitte S. Jensen +5 more
doaj +2 more sources
Case Report: Oleandrin intoxication by inhalation in beef cattle [PDF]
Frontiers in Veterinary ScienceOleander (Nerium oleander) contains more than 30 different toxic cardiac glycosides, including oleandrin. Intoxication can occur through ingestion or inhalation in several species, including cattle.
Anastasia Lisuzzo +11 more
doaj +2 more sources
Discovery of senolytics using machine learning [PDF]
Nature Communications, 2023 Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection.
Vanessa Smer-Barreto +10 more
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Poisoning by Nerium oleander L. in Franconia Geese [PDF]
AnimalsThis study describes the acute poisoning of four 3-month-old Franconia geese (Anser anser) by oleander plants (Nerium oleander). After the accidental ingestion of oleander clippings, the geese exhibited a rapid onset of severe symptoms, leading to ...
Nicola Pugliese +12 more
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Dose-response assessment of neuroactive botanical extracts and their bioactive constituents using microelectrode array (MEA) recordings in rat primary cortical cultures [PDF]
Pharmaceutical BiologyContext Use of botanicals is increasing. While often considered as safe, neuromodulatory effects have been demonstrated previously.Objective Establish the neuroactive potential of 13 botanical extracts.
Regina G. D. M. van Kleef +4 more
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Human Deaths Related to Oleander Poisoning: A Review of the Literature [PDF]
ToxinsOleander poisoning, resulting from the ingestion of Nerium oleander or Thevetia peruviana, is a serious toxicological issue in various parts of the world, particularly in regions where these plants grow abundantly and are easily accessible.
Matteo Antonio Sacco +8 more
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Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19 [PDF]
Cell & BioscienceBackground Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial role in both ...
Dat P. Ha +12 more
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PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death [PDF]
Neoplasia: An International Journal for Oncology ResearchSuccessful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and
Sharmistha Chakraborty +5 more
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Engineered RegenerationInflammation can initiate osteolysis, which is the breakdown of bone by fully developed osteoclasts. The compound Oleandrin is recognized for its effects against inflammation and tumors.
Zhikun Li, Ruijun Xu, Ruixi Hu
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