Results 21 to 30 of about 873 (179)

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19 [PDF]

Cell & Bioscience
Background Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial role in both ...
Dat P. Ha, Woo-Jin Shin, Ze Liu, Michael E. Doche, Roy Lau, Nektaria Maria Leli, Crystal S. Conn, Mariangela Russo, Annalisa Lorenzato, Constantinos Koumenis, Min Yu, Shannon M. Mumenthaler, Amy S. Lee   +12 more
doaj   +2 more sources

PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death [PDF]

Neoplasia: An International Journal for Oncology Research
Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and
Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang   +5 more
doaj   +2 more sources

Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption

Engineered Regeneration
Inflammation can initiate osteolysis, which is the breakdown of bone by fully developed osteoclasts. The compound Oleandrin is recognized for its effects against inflammation and tumors.
Zhikun Li, Wei Xu, Ruijun Xu
exaly   +3 more sources

Antifibrotic Effect of Ethanolic Extract of Nerium indicum Mill. Standardized 5α-Oleandrin on Keloid Fibroblasts Cells [PDF]

Majalah Obat Tradisional, 2018
Keloid is a skin lesion caused by an abnormal proliferation of fibroblasts and the deposition of collagen in the wound healing process. Therapy for keloids is relatively limited and mostly has side effects.
Mae Sri Hartati Wahyuningsih, Fara Silvia Yuliani, Dwiki Yuliya Rahmawati, Annisa Nurul Pratiwi   +3 more
doaj   +2 more sources

Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect [PDF]

Journal of Physiological Sciences
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death.
Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu, Hideki Sakai   +4 more
doaj   +2 more sources

Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo [PDF]

Molecules, 2023
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth   +9 more
doaj   +2 more sources

A Probable Fatal Case of Oleander (Nerium oleander) Poisoning on a Cattle Farm: A New Method of Detection and Quantification of the Oleandrin Toxin in Rumen [PDF]

Toxins, 2019
Oleander (Nerium oleander) is an ornamental plant common in tropical and sub-tropical regions that is becoming increasingly widespread, even in temperate regions. Oleander poisoning may occur in animals and humans. The main active components contained in
Silva Rubini, Sabina Strano Rossi, Serena Mestria, Sara Odoardi, Sara Chendi, Andrea Poli, Giuseppe Merialdi, Giuseppina Andreoli, Paolo Frisoni, Rosa Maria Gaudio, Anna Baldisserotto, Piergiacomo Buso, Stefano Manfredini, Guido Govoni, Stefania Barbieri, Cinzia Centelleghe, Giorgia Corazzola, Sandro Mazzariol, Carlo Alessandro Locatelli   +18 more
doaj   +3 more sources

DAMINOZIDE APPLICATION METHOD EFFECT ON GROWTH AND CONTENTS OF OLEANDRIN AND RUTIN OF OLEANDER (NERIUM OLEANDER L.) [PDF]

Scientific Journal of Flowers and Ornamental Plants, 2017
This study included one factor with four growth retardant application methods of daminozide at 500 mg.l-1 concentration (without addition, sapling base soaking, drench, and spraying methods) on oleander sapling four months age.
Zyad Al-Fathul, Mohamed Al-Nijady, Taha Ahmed, Ali Qasim   +3 more
doaj   +3 more sources

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro. [PDF]

Vet Med Sci
YSK‐AB, a botanical mixture, reduced nitric oxide production in RAW 264.7 cells and chemokine expression in canine keratinocytes, suggesting its potential as a natural therapeutic agent for inflammatory skin diseases in dogs. ABSTRACT Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases ...
Ha D, Jung K, Choi H, Yoon JS.
europepmc   +2 more sources