Results 21 to 30 of about 665 (160)
Molecules, 2020 Oleandrin, the main component of Nerium oleander L. extracts, is a cardiotoxic glycoside with multiple pharmacological implications, having potential anti-tumoral and antiviral characteristics. Although it is accepted that the main mechanism of oleandrin
Lavinia L. Ruta +2 more
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Cardiac Glycoside Oleandrin Suppresses EMT Ability in Endometrial Carcinoma Cells. [PDF]
Int J Mol Cell Med, 2023 Endometrial carcinoma is one of the most common types of cancer among women. The progression of cancer occurs via the Epithelial- Mesenchymal Transition (EMT) pathway. Cells lose their epithelial properties and become mobile. For this reason, the EMT process is one of the most important step to be targeted in cancer treatment.
Secer Celik F, Eroglu Gunes C, Kurar E.
europepmc +3 more sources
Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS [PDF]
Fayixue Zazhi, 2018 Objective To develop a liquid chromatography-tandem mass spectrometry （LC-MS/MS） analytical method for the determination of oleandrin in blood and liver tissues, which could be applied to the cases of death caused by oleander poisoning.
ZHAI Jin-xiao, YAN Hui, SHEN Min，et al.
doaj +1 more source
Frontiers in Pharmacology, 2022 Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low ...
Alessandro Colapietro +14 more
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Biliary parascarosis in a foal
Veterinary Medicine and Science, Volume 9, Issue 3, Page 1149-1153, May 2023., 2023 Here we report finding of an adult male Parascaris nematode in the junction of the lobar duct and left hepatic duct during necropsy of a 6‐month‐old female foal who died because of oleander (Nerium oleander) intoxication. Abstract Migration of Ascaris lumbricoides through the papilla of Vater in humans, and entry into the biliary tree, is well ...
Alireza Sazmand +4 more
wiley +1 more source
Ecology and Evolution, Volume 13, Issue 4, April 2023., 2023 We raised milkweed bugs on artificial diets with increasing quantities of cardenolides and then examined how this affected oxidative state and signal quality (brightness and chroma) across different life stages. Glutathione decreased in all individuals with increasing levels of sequestered cardenolides.
H. Cecilia Heyworth +5 more
wiley +1 more source
Molecules, 2021 Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir +5 more
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BioMed Research International, Volume 2023, Issue 1, 2023., 2023 Cosmetics and personal care items are used worldwide and administered straight to the skin. The hazardous nature of the chemical surfactant utilized in the production of cosmetics has caused alarm on a global scale. Therefore, bacterial biosurfactants (BS) are becoming increasingly popular in industrial product production as a biocompatible, low‐toxic ...
Arun Karnwal +9 more
wiley +1 more source
Stimuli‐responsive crosslinked nanomedicine for cancer treatment
Exploration, Volume 2, Issue 6, December 2022., 2022 We classify the stimuli‐responsive crosslinked nanomedicines (SCNs) into three categories based on the crosslinking strategies, including built‐in, on‐surface, and inter‐particle crosslinking nanomedicines. These SCNs can respond to particular tumoral stimuli and go through a series of dynamic changes to circumvent different biological barriers, and ...
Xiangdong Xue, Haijing Qu, Yuanpei Li
wiley +1 more source
Frontiers in Pharmacology, 2022 Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of
Sara Vaccaro +30 more
doaj +1 more source