Results 31 to 40 of about 873 (179)

Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer

open access: yesCell Death and Disease, 2021
Chemotherapeutic agents have been linked to immunogenic cell death (ICD) induction that is capable of augmenting anti-tumor immune surveillance. The cardiac glycoside oleandrin, which inhibits Na+/K+-ATPase pump (NKP), has been shown to suppress breast ...
Xiaoxi Li   +5 more
doaj   +1 more source

The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma

open access: yesFrontiers in Pharmacology, 2022
Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low ...
Alessandro Colapietro   +14 more
doaj   +1 more source

Figure 19. Sulfated galactan, Figure 20. Oleandrin

open access: yes, 2022
   Figure 19. Sulfated galactan spiderchem ID : N/A Figure 20.
Adryan Fristiohady (12512725)
core   +1 more source

Biliary parascarosis in a foal

open access: yesVeterinary Medicine and Science, Volume 9, Issue 3, Page 1149-1153, May 2023., 2023
Here we report finding of an adult male Parascaris nematode in the junction of the lobar duct and left hepatic duct during necropsy of a 6‐month‐old female foal who died because of oleander (Nerium oleander) intoxication. Abstract Migration of Ascaris lumbricoides through the papilla of Vater in humans, and entry into the biliary tree, is well ...
Alireza Sazmand   +4 more
wiley   +1 more source

New Cardenolides from Biotransformation of Gitoxigenin by the Endophytic Fungus Alternaria eureka 1E1BL1: Characterization and Cytotoxic Activities

open access: yesMolecules, 2021
Microbial biotransformation is an important tool in drug discovery and for metabolism studies. To expand our bioactive natural product library via modification and to identify possible mammalian metabolites, a cytotoxic cardenolide (gitoxigenin) was ...
Erdal Bedir   +5 more
doaj   +1 more source

Development of α-Selective Glycosylation with l-Oleandral and Its Application to the Total Synthesis of Oleandrin. [PDF]

open access: yesOrg Lett, 2023
This letter describes the development of an α-selective glycosylation using l-oleandrose, a 2-deoxysugar that is frequently found in natural products, and its application to the total synthesis of the natural cardiotonic steroids oleandrin and ...
Carney N   +3 more
europepmc   +2 more sources

Antioxidant availability trades off with warning signals and toxin sequestration in the large milkweed bug (Oncopeltus fasciatus)

open access: yesEcology and Evolution, Volume 13, Issue 4, April 2023., 2023
We raised milkweed bugs on artificial diets with increasing quantities of cardenolides and then examined how this affected oxidative state and signal quality (brightness and chroma) across different life stages. Glutathione decreased in all individuals with increasing levels of sequestered cardenolides.
H. Cecilia Heyworth   +5 more
wiley   +1 more source

Microbial Biosurfactant as an Alternate to Chemical Surfactants for Application in Cosmetics Industries in Personal and Skin Care Products: A Critical Review

open access: yesBioMed Research International, Volume 2023, Issue 1, 2023., 2023
Cosmetics and personal care items are used worldwide and administered straight to the skin. The hazardous nature of the chemical surfactant utilized in the production of cosmetics has caused alarm on a global scale. Therefore, bacterial biosurfactants (BS) are becoming increasingly popular in industrial product production as a biocompatible, low‐toxic ...
Arun Karnwal   +9 more
wiley   +1 more source

The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

open access: yesFrontiers in Pharmacology, 2022
Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of
Sara Vaccaro   +30 more
doaj   +1 more source

Stimuli‐responsive crosslinked nanomedicine for cancer treatment

open access: yesExploration, Volume 2, Issue 6, December 2022., 2022
We classify the stimuli‐responsive crosslinked nanomedicines (SCNs) into three categories based on the crosslinking strategies, including built‐in, on‐surface, and inter‐particle crosslinking nanomedicines. These SCNs can respond to particular tumoral stimuli and go through a series of dynamic changes to circumvent different biological barriers, and ...
Xiangdong Xue, Haijing Qu, Yuanpei Li
wiley   +1 more source

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