Results 51 to 60 of about 665 (160)
Food Frontiers, Volume 7, Issue 1, January 2026.The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima +15 more
wiley +1 more source
Journal of Microbiology and Infectious Diseases, 2023 Background: In-silico analysis and molecular docking tools offer alternative ploy to characterize the virulence factors of Edwardsiella tarda and identify potential herbal antimicrobial compounds as substitutes to overcome the adverse health effects of ...
Balakrishnan Naveen Rajeshwar +1 more
doaj +1 more source
Advanced Science, Volume 12, Issue 46, December 11, 2025.Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye +9 more
wiley +1 more source
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander [PDF]
Journal of Experimental Therapeutics and Oncology, 2002 Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel™, were conducted in mice after either an i.v. dose (40 μg/kg) or a p.o. dose (80 μg/kg). Oleandrin was rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half‐life was longer (2.3 ± 0.5 h) than that after i.v. dosing (0.4 ± 0.1 h).
Dan, Ni +5 more
openaire +4 more sources
Frontiers in Animal ScienceBackgroundInfection by porcine respiratory and reproductive syncytial virus (PRRSV), swine influenza virus (SIV) and porcine epidemic diarrhea (PEDV) adversely affect worldwide pig production.
Robert A. Newman +5 more
doaj +1 more source
Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets
MedComm, Volume 6, Issue 7, July 2025.Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky +9 more
wiley +1 more source
ChemistryOpen, Volume 14, Issue 3, March 2025.The review explores the latest updates (2013–2024) and information about pesticidal plants (22 plant species) that are distributed across Africa and offers insights into the integration of nanoformulated natural compounds as a more sustainable option to control desert locust invasions.
Patrick Mangundu +6 more
wiley +1 more source
Plant‐derived compounds as potential leads for new drug development targeting COVID‐19
Phytotherapy Research, Volume 38, Issue 3, Page 1522-1554, March 2024.Abstract COVID‐19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Although some patients infected with COVID‐19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough,
Lingxiu Liu, Maxim Kapralov, Mark Ashton
wiley +1 more source
Toxins, 2019 Oleander (Nerium oleander) is an ornamental plant common in tropical and sub-tropical regions that is becoming increasingly widespread, even in temperate regions. Oleander poisoning may occur in animals and humans. The main active components contained in
Silva Rubini +18 more
doaj +1 more source
Cardiac Glycoside Plants Self-Poisoning
Acta Medica Bulgarica, 2014 Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander, Convallaria majalis (lily of the valley), Strophanthus gratus, etc.
Radenkova-Saeva J., Atanasov P.
doaj +1 more source