Results 61 to 70 of about 873 (179)

In silico analysis, modelling and docking studies on the etfB and etfC virulence proteins of the fish pathogen Edwardsiella tarda

Journal of Microbiology and Infectious Diseases, 2023
Background: In-silico analysis and molecular docking tools offer alternative ploy to characterize the virulence factors of Edwardsiella tarda and identify potential herbal antimicrobial compounds as substitutes to overcome the adverse health effects of ...
Balakrishnan Naveen Rajeshwar, Thangapalam Jawahar Abraham   +1 more
doaj   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander [PDF]

Journal of Experimental Therapeutics and Oncology, 2002
Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel™, were conducted in mice after either an i.v. dose (40 μg/kg) or a p.o. dose (80 μg/kg). Oleandrin was rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half‐life was longer (2.3 ± 0.5 h) than that after i.v. dosing (0.4 ± 0.1 h).
Dan, Ni, Timothy L, Madden, Mary, Johansen, Edward, Felix, Dah H, Ho, Robert A, Newman   +5 more
openaire   +4 more sources

Renal Lesions in Horses with Oleander (Nerium oleander) Poisoning

Animals, 2022
A presumptive postmortem diagnosis of oleander (Nerium oleander) poisoning is made based on the histological observation of cardiomyocyte degeneration and necrosis, which is considered to be a reliable diagnostic marker, and can be confirmed via the ...
Chelsea A. Sykes, Francisco A. Uzal, Aslı Mete, Jennine Ochoa, Michael Filigenzi, Robert H. Poppenga, Javier Asin   +6 more
doaj   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

The cardiovascular effects of oleandrin in the dog

, 1977
Vita.The effects of oleandrin, a cardiac glycoside, were studied on a number of hemodynamic parameters and on left ventricular contractility in five groups of morphine-chloralose anesthetized dogs with a "normal" heart and intact circulation.
Deavers, Stephanie Ipper
core   +1 more source

Plant‐Derived Natural Products and Their Nano Transformation: A Sustainable Option Towards Desert Locust Infestations

ChemistryOpen, Volume 14, Issue 3, March 2025.
The review explores the latest updates (2013–2024) and information about pesticidal plants (22 plant species) that are distributed across Africa and offers insights into the integration of nanoformulated natural compounds as a more sustainable option to control desert locust invasions.
Patrick Mangundu, Rebaone Makaudi, Hugues Kamdem Paumo, Bathabile Ramalapa, Lesego Tshweu, Naledi Raleie, Lebogang Katata‐Seru   +6 more
wiley   +1 more source

Prophylactic and Therapeutic Inhibition of In Vitro SARS-CoV-2 Replication by Oleandrin [PDF]

, 2020
ABSTRACT With continued expansion of the COVID-19 pandemic, antiviral drugs are desperately needed to treat patients at high risk of life-threatening disease and even to limit spread if administered early during infection. Typically, the fastest route to identifying and licensing a safe and effective antiviral drug is
Kenneth S. Plante, Jessica A. Plante, Diana Fernandez, Divya Mirchandani, Nathen Bopp, Patricia V. Aguilar, K. Jagannadha Sastry, Robert A. Newman, Scott C. Weaver   +8 more
openaire   +2 more sources

Cardiac Glycoside Plants Self-Poisoning

Acta Medica Bulgarica, 2014
Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander, Convallaria majalis (lily of the valley), Strophanthus gratus, etc.
Radenkova-Saeva J., Atanasov P.
doaj   +1 more source