Results 81 to 90 of about 873 (179)

Neuroprotective and tumoricidal activities of cardiac glycosides: Could oleandrin be a new weapon against stroke and glioblastoma?

, 2018
Cardiac glycosides induce a strong immunological cancer cell cytotoxicity, in which the released intracellular components of dying tumor cells (e.g. calreticulin, HMGB1 and ATP) stimulate immunity and help in eradicating cancer.
Elmaci, Ilhan, Aysel Ozpinar, Cengiz, Salih, Meric A. Altinoz, Ozpinar, Aysel, İlhan Elmaci, Salih Cengiz, Altinoz, Meric A., Ebru Emekli Alturfan, Alturfan, Ebru Emekli   +9 more
core   +2 more sources

Investigation of the Effects of Oleandrin on Cell Survival and Cell Death Mechanisms in HEPG2 Liver Cancer Cell With Increased miR-21 Expression [PDF]

Yüksek lisans tezi.Hepatosellüler karsinom (HCC) primer karaciğer kanserlerinin %82'sini oluşturmaktadır. Kansere bağlı ölümlerin üçüncü ana sebebidir.
KARAKAYA, EBRAR
core   +1 more source

Network pharmacology-based toxicity, molecular docking, and molecular dynamics analysis of phytoconstituents from roots of Nerium indicum L

Pharmacological Research - Modern Chinese Medicine
Background: Herbal medicine plays a vital role in healthcare, but safety concerns arise due to potential toxicity risks. Nerium indicum (夹竹桃, jiā zhú táo) is used in Chinese herbal medicine for its therapeutic effects, yet it contains toxic cardiac ...
Veerkumar P. Japti, Mrityunjaya B. Patil, Banappa S. Unger, Shamanand P. Mallapur, Akshay Shamnewadi, Vishal S. Patil, Sathgowda Patil, Anand V. Desai   +7 more
doaj   +1 more source

CG-dependent reduction of PrP^C levels depends on CG-ATP1A1 ligand-receptor engagement.

, 2022
(A) Predicted oleandrin binding pose modeled in ATP1A1 structure reported in PDB entry 4HYT. (B) Genetic sequencing results confirm successful amino acid substitutions Q118R and N129D, two changes required to render the human ATP1A1 resistant to CGs, in ...
Xinzhu Wang (1575541), Gerold Schmitt-Ulms (195668), Muhammad Sulman (12988414), Wenda Zhao (11772814), Mark Grinberg (12988408), Declan Williams (1792693), Christopher Sackmann (3605624), Mohadeseh Mehrabian (455336), Murdock Siegner (12988411), Bei Qi Yan (12988405), Shehab Eid (11772811)   +10 more
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Deteksi mekanisme apoptosis sel kanker ginjal pada pemberian senyawa 16,17-dehidrode-asetil-5alpha-oleandrin hasil isolasi daun Nerium indicum Mill

, 2008
16,17-dehidrodeasetil-Sa-oleandrin nierupakan senyawa golongan kardenolida yang diisolasi dari fraksi aktif daun Nerium indicum Mill (fam. Apocynaceae).
Perpustakaan UGM, i-lib
core   +2 more sources

Identification of Oleandrin and other Cardenolides with Anticancer Activity in Methanolic Extracts from Plants of the Apocynaceae Family [PDF]

, 2020
Cardenolides are a family of steroid-type compounds, which due to their biological activity, have become consolidated as possible anticancer agents.
Cotacachi Latacumba, Paul Esteban
core   +1 more source

Erratum: The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, is Synergistic With Radiotherapy in Models of Human Glioblastoma

Frontiers in Pharmacology, 2022
Frontiers Production Office
doaj   +1 more source

Cytotoxic effect of oleandrin on various cancer cells with aldosterone presents

, 2014
Sağlık Bilimleri Enstitüsü, Farmakoloji Ana Bilim DalıBu çalışmada Nerium oleander (zakkum) bitkisinden elde edilen ve bir kardiyak glikozit olan oleandrinin A549 akciğer kanseri ve MCF7 meme kanseri hücreleri üzerinde tek başına ve aldosteron varlığında
Yerlikaya, Hale Nur
core   +1 more source

Synthetic Approach to the Core Structure of Oleandrin and Related Cardiac Glycosides with Highly Functionalized Ring D

, 2016
The first synthetic approach to the core structure of cardiac glycoside oleandrin exhibiting a potent cytotoxic activity, starting from a common androstane derivative, has been accomplished.
Karol Michalak (2168737), Maja Morawiak (1580809), Jerzy Wicha (2168740)   +2 more
core   +1 more source

UHPLC-MS/MS determination of oleandrin in blood and tissues of dairy cattle poisoned by oleander (Nerium oleander)

, 2019
The accidental ingestion of leaves or cut branches of oleander (Nerium oleander) often results in severe poisoning in cattle. This natural shrub contains oleandrin, a highly toxic cardiac glycoside, which may prove fatal even at very low amounts.
Carelli G., Nebbia, C., Ceci L., Gosetti F., Marengo E., Marengo, Emilio, Carelli, Grazia, Gosetti, Fabio, Nebbia, Carlo, Nebbia C., Ceci, Luigi   +10 more
core   +1 more source