The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma [PDF]
Frontiers in Pharmacology, 2022 Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low ...
Alessandro Colapietro +2 more
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The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo [PDF]
Frontiers in Pharmacology, 2022 Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of
Silvia Codenotti +2 more
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Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions [PDF]
Molecules, 2023 The Nerium oleander extract PBI 05204 (PBI) and its cardiac glycoside constituent oleandrin have direct anti-viral properties. Their effect on the immune system, however, is largely unknown. We used an in vitro model of human peripheral blood mononuclear
Gitte S Jensen +2 more
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The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties [PDF]
Frontiers in Pharmacology, 2020 Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts.
Alessandro Colapietro +2 more
exaly +4 more sources
PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death [PDF]
NeoplasiaSuccessful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs) and
Sharmistha Chakraborty +2 more
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Antiviral effects of oleandrin. [PDF]
J Am Coll Emerg Physicians Open, 2021 Journal of the American College of Emergency Physicians Open, Volume 2, Issue 3, June 2021.
Newman R, Jagannadha Sastry K.
europepmc +2 more sources
Erratum: The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, is Synergistic With Radiotherapy in Models of Human Glioblastoma [PDF]
Frontiers in Pharmacology, 2022 Frontiers Production Office
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Natural Products as Adjunctive Treatment for Pancreatic Cancer: Recent Trends and Advancements. [PDF]
Biomed Res Int, 2017 Pancreatic cancer is a type of common malignant tumors with high occurrence in the world. Most patients presented in clinic had pancreatic cancer at advanced stages. Furthermore, chemotherapy or radiotherapy had very limited success in treating pancreatic cancer.
Yue Q, Gao G, Zou G, Yu H, Zheng X.
europepmc +2 more sources
Frontiers in Animal ScienceBackgroundInfection by porcine respiratory and reproductive syncytial virus (PRRSV), swine influenza virus (SIV) and porcine epidemic diarrhea (PEDV) adversely affect worldwide pig production.
Robert A Newman +2 more
exaly +3 more sources
Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health [PDF]
Antiviral Chemistry and Chemotherapy, 2022 Robert A Newman +2 more
exaly +2 more sources