A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma [PDF]
Oncologist, 2020 Abstract Lessons Learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the most common side effects related to treatment being ...
Dana Backlund Cardin +2 more
exaly +5 more sources
Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke [PDF]
Scientific Reports, 2016 AbstractWe previously reported neuroprotective activity of the botanical anti-cancer drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, in brain slice and in vivo models of ischemic stroke. We showed that one component of this neuroprotective activity is mediated through its principal cardiac glycoside constituent, oleandrin, via
Michael J Van Kanegan +2 more
exaly +4 more sources
PBI-05204, a supercritical CO₂ extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway. [PDF]
Invest New Drugs, 2015 SummaryIntroduction Oleandrin, a cardiac glycoside, exerts strong anti-proliferative activity against various human malignancies in in vitro cells. Here, we report the antitumor efficacy of PBI-05204, a supercritical C02 extract of Nerium oleander containing oleandrin, in a human pancreatic cancer Panc-1 orthotopic model.
Pan Y +11 more
europepmc +3 more sources
Cancer Research, 2022 Abstract Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low life expectancy.
Colapietro, Alessandro +10 more
openaire +3 more sources
The FEBS Journal, Volume 286, Issue 18, Page 3510-3539, September 2019., 2019 The Src signalling cascade has been recognised as a key driver of pancreatic tumourigenesis, disease progression and therapeutic resistance, and plays an important role in mediating the dynamic crosstalk that occurs between tumour cells and their surrounding microenvironment.
Ashleigh Parkin +3 more
wiley +1 more source
The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012 Since publishing our earlier report describing a strategy for the treatment of central nervous system (CNS) diseases by inhibiting the cell cycle and without disrupting neurogenesis (Liu et al. 2010), we now update and extend this strategy to applications in the treatment of cancers as well.
Da-Zhi Liu +3 more
wiley +1 more source
Dermatology Research and Practice, Volume 2012, Issue 1, 2012., 2012 Although advances in cytotoxic treatments have been obtained in several neoplasias, in metastatic melanoma there was no drug able to significantly change the natural history of the disease in the last 30 years. In the last decade, translational research identified important mechanisms in malignant transformation, invasion, and progression.
Felipe Ades +2 more
wiley +1 more source
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine. [PDF]
Front Pharmacol, 2023 Adnan M, Pasupuleti VR, Patel M.
europepmc +1 more source
Editorial: Insights in pharmacology of anti-cancer drugs: 2021. [PDF]
Front Pharmacol, 2022 Sancho P, Feron O.
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Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2. [PDF]
Biomed Pharmacother, 2021 Plante KS +16 more
europepmc +1 more source