Results 31 to 40 of about 133 (76)

Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. [PDF]

Cell Death Dis, 2021
Li X, Zheng J, Chen S, Meng FD, Ning J, Sun SL.   +5 more
europepmc   +1 more source

Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies. [PDF]

Nutrients, 2022
Triantafillidis JK, Triantafyllidi E, Sideris M, Pittaras T, Papalois AE.   +4 more
europepmc   +1 more source

Interaction of (+)-Strebloside and Its Derivatives with Na⁺/K⁺-ATPase and Other Targets. [PDF]

Molecules, 2021
Ren Y, Wu S, Chen S, Burdette JE, Cheng X, Kinghorn AD.   +5 more
europepmc   +1 more source

Na+, K+-ATPase阻害薬PBI-05204による脳虚血傷害後の治療効果の検討

Na+, K+-ATPase阻害薬PBI-05204による脳虚血傷害後の治療効果の検討
論文(Article) 【背景】脳虚血障害においてNa+, K+-ATPase 活性は低下することが知られているNa+/Ca2+交換系も障害されるため、細胞内Ca2+濃度の上昇から神経細胞死が誘発されると考えられている。一方で、Na+,K+-ATPase 阻害薬であるPBI-05204 (PBI) やその主要成分が高い脳血管関門通過性をもち、脳由来神経栄養因子(BDNF)を上昇させ、脳神経細胞保護効果を示すことが報告された。PBIは抗腫瘍薬として既に臨床応用の可能性が示唆されている薬物である。今回、我々はPBI による脳虚血障害後の神経保護作用を成熟ラット中大脳動脈虚血再還流（MCAO) モデルを用いて詳細に検討した。 【方法】MCAOモデルは雄性成熟Wisterラットを用いて ...
openaire  

Anticancer and Immunogenic Properties of Cardiac Glycosides. [PDF]

Molecules, 2017
Schneider NFZ, Cerella C, Simões CMO, Diederich M.   +3 more
europepmc   +1 more source

BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin. [PDF]

J Neurosci, 2014
Van Kanegan MJ, He DN, Dunn DE, Yang P, Newman RA, West AE, Lo DC.   +6 more
europepmc   +1 more source

Natural Compounds That Target Glioma Stem Cells. [PDF]

NeuroSci
Yaroshenko M, Christoff M, Ścibiorski M, Surowiec K, Jakubowicz-Gil J, Sumorek-Wiadro J.   +5 more
europepmc   +1 more source

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. [PDF]

Nat Commun, 2023
Nguyen LD, Wei Z, Silva MC, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM.   +11 more
europepmc   +1 more source

PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells. [PDF]

Int J Mol Sci, 2021
Seifert C, Balz E, Herzog S, Korolev A, Gaßmann S, Paland H, Fink MA, Grube M, Marx S, Jedlitschky G, Tzvetkov MV, Rauch BH, Schroeder HWS, Bien-Möller S.   +13 more
europepmc   +1 more source

Inhibition of the PI3K/AKT/mTOR pathway in pancreatic cancer: is it a worthwhile endeavor? [PDF]

Ther Adv Med Oncol
Ouissam AJ, Hind C, Sami Aziz B, Said A.
europepmc   +1 more source