Results 51 to 60 of about 133 (76)

Akt inhibitors in clinical development for the treatment of cancer. [PDF]

Expert Opin Investig Drugs, 2010
Pal SK, Reckamp K, Yu H, Figlin RA.
europepmc   +1 more source

Cardiac glycosides: Looking beyond heart failure and atrial fibrillation.

Indian J Pharmacol
Omole JG, Udom GJ, Aturamu A, Agbana RD, Aziakpono OM, Oritsemuelebi B, Bukke SPN, Okon IA, Yemitan OK.   +8 more
europepmc   +1 more source

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19. [PDF]

Cell Biosci
Ha DP, Shin WJ, Liu Z, Doche ME, Lau R, Leli NM, Conn CS, Russo M, Lorenzato A, Koumenis C, Yu M, Mumenthaler SM, Lee AS.   +12 more
europepmc   +1 more source

Current management and future directions in metastatic pancreatic adenocarcinoma. [PDF]

Cancer, 2016
Varghese AM, Lowery MA, Yu KH, O'Reilly EM.   +3 more
europepmc   +1 more source

The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells. [PDF]

J Neurosci, 2017
Garofalo S, Grimaldi A, Chece G, Porzia A, Morrone S, Mainiero F, D'Alessandro G, Esposito V, Cortese B, Di Angelantonio S, Trettel F, Limatola C.   +11 more
europepmc   +1 more source

Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke.

Neural Regen Res, 2015
Yu QJ, Tao H, Wang X, Li MC.
europepmc   +1 more source

Oleandrin: A cardiac glycosides with potent cytotoxicity.

Pharmacogn Rev, 2013
Kumar A, De T, Mishra A, Mishra AK.
europepmc   +1 more source

Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer therapy? [PDF]

Investigational New Drugs, 2015
JOSÉ Manuel Calderón-Montaño, Estefania Burgos-Morón, Emilio Guillén-Mancina   +2 more
exaly   +3 more sources

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Response to: Does the Nerium oleander extract PBI-05204 have potential for pancreatic cancer?

Investigational New Drugs, 2015
Robert A Newman, Peiying Yang, Newman Robert A   +2 more
exaly   +3 more sources

First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors

Investigational New Drugs, 2014
PBI-05204, a Nerium oleander extract (NOE) containing the cardiac glycoside oleandrin, inhibits the α-3 subunit of Na-K ATPase, as well as FGF-2 export, Akt and p70S6K, hence attenuating mTOR activity. This first-in-human study determined the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of PBI-05204 in patients with advanced cancer.
D S Hong, A Naing, S Moulder
exaly   +3 more sources