Results 11 to 20 of about 665 (160)

Function of inhibition of RNA virus replication by digoxin and oleandrin [PDF]

Xin yixue, 2023
Objective To evaluate the antiviral ability of cardiac glycosides of digoxin and oleandrin. Methods Human adenocarcinoma alveolar basal epithelial cell line （A549） and African green monkey kidney cell line （vero） were used for subsequent experiment.
Liao Xialin, Liang Wei, Chen Jiawen, Liu Kunpeng
doaj   +2 more sources

The effect of 5α-oleandrin on keloid fibroblast activities [PDF]

BMC Proceedings, 2019
Background Keloids develop due to hyperactivity of keloid fibroblast (KF) in proliferation, migration, and collagen deposition along with low rates of collagen degradation.
Ishandono Dachlan, Yohanes Widodo Wirohadidjojo, Mae Sri Hartati Wahyuningsih, Teguh Aryandono, Hardyanto Soebono, Dwiki Afandy   +5 more
doaj   +3 more sources

Antiviral Effects of Oleandrin

Journal of Experimental Pharmacology, 2020
Robert A Newman, 1, 2 K Jagannadha Sastry, 3 Ravit Arav-Boger, 4 Hongyi Cai, 5 Rick Matos, 6 Robert Harrod 7 1Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA; 2Phoenix Biotechnology,
Newman RA, Sastry KJ, Arav-Boger R, Cai H, Matos R, Harrod R   +5 more
doaj   +3 more sources

Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect [PDF]

Journal of Physiological Sciences
Cardiac glycosides, known as inhibitors of Na+,K+-ATPase, have anti-cancer effects such as suppression of cancer cell proliferation and induction of cancer cell death.
Mizuki Katoh, Takuto Fujii, Yoshiaki Tabuchi, Takahiro Shimizu, Hideki Sakai   +4 more
doaj   +2 more sources

Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo [PDF]

Molecules, 2023
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth   +9 more
doaj   +2 more sources

Renal Lesions in Horses with Oleander (Nerium oleander) Poisoning [PDF]

Animals, 2022
A presumptive postmortem diagnosis of oleander (Nerium oleander) poisoning is made based on the histological observation of cardiomyocyte degeneration and necrosis, which is considered to be a reliable diagnostic marker, and can be confirmed via the ...
Chelsea A. Sykes, Francisco A. Uzal, Aslı Mete, Jennine Ochoa, Michael Filigenzi, Robert H. Poppenga, Javier Asin   +6 more
doaj   +2 more sources

Oleandrin Promotes Apoptosis in an Autophagy-Dependent Manner in Gastric Cancer

Frontiers in Bioscience-Landmark
Background: The medicinal phytochemical oleandrin (Ole) is obtained from the Nerium oleander plant. The exact relationship between Ole-induced apoptosis and autophagy in gastric cancer (GC) is unclear despite the fact that it has ...
Xiaoyan Huang, Liting Yan, Xiangrong Zhao, Ying Wang, Huiting Li, Xinlu Jiang, Yangmeng Feng, Dandan Ouyang, Cuixiang Xu, Jianhua Wang   +9 more
doaj   +3 more sources

Antiviral effects of oleandrin [PDF]

Journal of the American College of Emergency Physicians Open, 2021
More importantly, our published studies demonstrated the safety of the plant extract in the Food and Drug Administration (FDA)-approved Phase I and II clinical trials in cancer patients through the use of our novel drug PBI-05204. [...]that is our current aim for PBI-05204.
R. Newman, K. Jagannadha Sastry
doaj   +3 more sources

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]

Chemistry
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N, Eid S, Schmitt-Ulms G, Nagorny P.   +3 more
europepmc   +2 more sources

Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer

Cell Death and Disease, 2021
Chemotherapeutic agents have been linked to immunogenic cell death (ICD) induction that is capable of augmenting anti-tumor immune surveillance. The cardiac glycoside oleandrin, which inhibits Na+/K+-ATPase pump (NKP), has been shown to suppress breast ...
Xiaoxi Li, Jian Zheng, Shi Chen, Fan-dong Meng, Jing Ning, Shu-lan Sun   +5 more
doaj   +1 more source