Results 11 to 20 of about 873 (179)

Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells

Molecules, 2020
Oleandrin, the main component of Nerium oleander L. extracts, is a cardiotoxic glycoside with multiple pharmacological implications, having potential anti-tumoral and antiviral characteristics. Although it is accepted that the main mechanism of oleandrin
Lavinia L. Ruta, Claudia V. Popa, Ileana C. Farcasanu   +2 more
doaj   +2 more sources

Oleandrin Promotes Apoptosis in an Autophagy-Dependent Manner in Gastric Cancer

Frontiers in Bioscience-Landmark
Background: The medicinal phytochemical oleandrin (Ole) is obtained from the Nerium oleander plant. The exact relationship between Ole-induced apoptosis and autophagy in gastric cancer (GC) is unclear despite the fact that it has ...
Xiaoyan Huang, Liting Yan, Xiangrong Zhao, Ying Wang, Huiting Li, Xinlu Jiang, Yangmeng Feng, Dandan Ouyang, Cuixiang Xu, Jianhua Wang   +9 more
doaj   +4 more sources

Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS [PDF]

Fayixue Zazhi, 2018
Objective To develop a liquid chromatography-tandem mass spectrometry （LC-MS/MS） analytical method for the determination of oleandrin in blood and liver tissues, which could be applied to the cases of death caused by oleander poisoning.
ZHAI Jin-xiao, YAN Hui, SHEN Min，et al.
doaj   +3 more sources

Efficacy of oleandrin and PBI-05204 against viruses of importance to commercial pig health management [PDF]

Frontiers in Animal Science
BackgroundInfection by porcine respiratory and reproductive syncytial virus (PRRSV), swine influenza virus (SIV) and porcine epidemic diarrhea (PEDV) adversely affect worldwide pig production.
Robert A. Newman, Robert A. Newman, Karim Abdelsalam, Robin Buterbaugh, K. Jagannadha Sastry, K. Jagannadha Sastry   +5 more
doaj   +2 more sources

The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells [PDF]

The Journal of Neuroscience, 2017
Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na+/K+-ATPase. In addition to its known effects on cardiac muscle, recentin vitroandin vivoevidence highlighted its potential for anticancer properties. Here, we evaluated for the first time the effect of oleandrin on brain tumors.
GAROFALO, STEFANO, GRIMALDI, ALFONSO, CHECE, Giuseppina, PORZIA, Alessandra, MORRONE, Stefania, MAINIERO, Fabrizio, D'ALESSANDRO, GIUSEPPINA, ESPOSITO, Vincenzo, Cortese, Barbara, DI ANGELANTONIO, SILVIA, TRETTEL, Flavia, LIMATOLA, Cristina   +11 more
openaire   +6 more sources

Negligible Oleandrin Content of Hot Dogs Cooked on Nerium oleander Skewers [PDF]

Journal of Medical Toxicology, 2020
The Nerium oleander plant contains cardenolides that may cause human poisoning when ingested. A long-standing belief holds that it is possible to be poisoned by eating hot dogs or other foods cooked on Nerium oleander branch skewers. Oleandrin levels in frankfurters cooked on fresh and dry Nerium oleander skewers were measured.Hot dogs were cooked ...
Jeffrey Suchard, Alexandra Greb
openaire   +6 more sources

Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Toxins, 2020
Cardiac glycosides (CGs) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to develop a targeted analytical method utilizing liquid chromatography—tandem mass spectrometry (LC-MS/MS) for
Julien Masquelier, Patrick P J Mulder
exaly   +3 more sources

Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish

International Journal of Neuroscience, 2019
Aim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson's disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone and mitoquinone for 30 days.
İsmail Ünal, Esin Çalışkan-Ak, Ünsal V. Üstündağ, Perihan S. Ateş, Ahmet A. Alturfan, Meric A. Altinoz, Ilhan Elmaci, Ebru Emekli-Alturfan   +7 more
core   +8 more sources

Dose-response assessment of neuroactive botanical extracts and their bioactive constituents using microelectrode array (MEA) recordings in rat primary cortical cultures [PDF]

Pharmaceutical Biology
Context Use of botanicals is increasing. While often considered as safe, neuromodulatory effects have been demonstrated previously.Objective Establish the neuroactive potential of 13 botanical extracts.
Regina G. D. M. van Kleef, J. Pepijn Wopken, Julie Krzykwa, Constance A. Mitchell, Remco H. S. Westerink   +4 more
doaj   +2 more sources

Human Deaths Related to Oleander Poisoning: A Review of the Literature [PDF]

Toxins
Oleander poisoning, resulting from the ingestion of Nerium oleander or Thevetia peruviana, is a serious toxicological issue in various parts of the world, particularly in regions where these plants grow abundantly and are easily accessible.
Matteo Antonio Sacco, Saverio Gualtieri, Aurora Princi, Alessandro Pasquale Tarallo, Maria Cristina Verrina, Lucia Tarda, Luca Calanna, Santo Gratteri, Isabella Aquila   +8 more
doaj   +2 more sources