Results 31 to 40 of about 31,015 (257)

Chiral peptidoglycan mimics target bacterial wall biosynthesis for pathogen intervention

Nature Communications
The global burden of microbial infections and antimicrobial resistance, coupled with the absence of precise bacterial recognition modalities, demands innovative breakthroughs in antibacterial treatment.
Kefurong Deng, Dongzhe Zou, Zenan Zeng, Beiling Guo, Wensheng Gong, Yini Xu, Yachao Li, Xianghui Xu   +7 more
doaj   +1 more source

Costs of avoiding net negative emissions under a carbon budget

Environmental Research Letters, 2021
The 2 °C and 1.5 °C temperature targets of the Paris Agreement can be interpreted as targets never to be exceeded, or as end-of-century targets. Recent literature proposes to move away from the latter, in favour of avoiding a temperature overshoot and ...
Kaj-Ivar van der Wijst, Andries F Hof, Detlef P van Vuuren   +2 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Paris targets within reach by aligning, broadening and strengthening net-zero pledges

Communications Earth & Environment
Many countries have recently announced the ambition to reach net-zero emissions targets. Here we explore the climate and energy transition impacts of the following strategies using the IMAGE integrated assessment model: 1) implementing the pledged 2030 ...
Ioannis Dafnomilis, Michel den Elzen, Detlef van Vuuren   +2 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

What makes policy for wind- and solar energy on land acceptable? An assessment of perceived policy legitimacy

Humanities & Social Sciences Communications
Large-scale changes in society are required to achieve policy goals for a transition to a sustainable energy system. Understanding how citizens perceive regional plans for the placement of wind and solar can help policymakers design their policy. Our aim
Astrid L. Martens, Jarry T. Porsius, Kees Vringer   +2 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Citizen’s perceived legitimacy of the Dutch natural gas-free heating policy

Environmental Research Communications
The Dutch Climate Agreement mandates sustainable heating of buildings by 2050, necessitating a transition away from natural gas towards electrification (heat pumps) and district heating.
Astrid Martens, Jarry T Porsius, Caren Herbstritt, Kees Vringer   +3 more
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Aerodynamic Performance and Impact Analysis of a MEMS-Based Non-Invasive Monitoring System for Wind Turbine Blades

IEEE Access
Wind power generation plays a key role in transitioning away from fossil fuel-dependent energy sources, contributing significantly to the mitigation of climate change.
Nicolas Scharer, Denis Mikhaylov, Cedric Sievi, Badoui Hanna, Caroline Braud, Julien Deparday, Sarah Barber, Tommaso Polonelli, Michele Magno   +8 more
doaj   +1 more source