Results 111 to 120 of about 154,598 (309)

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

CFSE^low PBMCs.

, 2019
Illustrates the average number of cells that have lost any level of CFSE labelling after 72 hours in culture during specific (HPV, SEA and SWAP), non-specific stimulation (CONA) and absence of stimulant (MED) in Schisto-infected+HPV, Schisto/PZQ+HPV and ...
Vicky Gent (7310216), Lucy Ochola (7310222), Thomas Kariuki (271512), Rebecca Waihenya (709338), Lucy Kamau (3514073), Ruth Nyakundi (7310219), Peris Ambala (4376563)   +6 more
core   +1 more source

mRNA gene expression in PBMCs of both MSM groups.

, 2022
mRNA gene expression in PBMCs of both MSM groups.
Mauricio Rojas (173910), Juan C. Hernandez (9365387), Katherin Contreras-Ramírez (14237400), Wildeman Zapata (493213), Ana C. Ossa-Giraldo (14237397), Yurany Blanquiceth (9365375), Lizdany Flórez-Álvarez (9365372)   +6 more
core   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Interaction of enriched pDCs and PBMCs.

, 2013
PBMCs were generated from freshly-drawn blood from healthy human donors. PDCs were enriched by MACS technique from PBMCs derived from freshly prepared buffy coats from healthy human donors.
Andreas Hoeft (33118), Tobias Hilbert (416028), Jens M. Poth (416032), Christina Weisheit (416030), Georg Baumgarten (33122), Josef Bongartz (416029), Pascal Knüfermann (416031)   +6 more
core   +1 more source

Exercise-Conditioned Plasma and DNMT3B Concentration in PBMCs [PDF]

, 2015
DNA methylation is modifiable by acute and chronic exercise. DNA methyltransferases (DNMT) catalyze this process; however, there is a lack of literature concerning the specific mechanisms by which exercise‐induced modifications occur. Interleukin 6 (IL‐6)
Moran, Colin N., Horsburgh, Steven, Todryk, Stephen, Ansley, Les, Moran, Colin Neil, Toms, Christopher   +5 more
core   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Expression levels of CXCL4 in the peripheral blood of patients with alopecia areata and their clinical significance

Pifu-xingbing zhenliaoxue zazhi
Objective The aim of this study was to investigate the expression levels of CXCL4 in the peripheral blood of patients with alopecia areata and to provide evidence for the pathogenesis of alopecia areata and the development of new therapeutic targets ...
XIAO Yufei, LIU Fang, HE Qianqian, HUANG Xing, YANG Ying, YANG Ying   +5 more
doaj   +1 more source

Intrauterine CRH‐treated PBMC in repeated implantation failure

European Journal of Clinical Investigation, 2019
AbstractBackgroundThe intrauterine administration of activated autologous peripheral blood monocytes (PBMC) prior to embryo transfer seems to improve reproductive outcomes in women with repeated implantation failure (RIF). We have previously shown that the intrauterine administration of PBMC treated with corticotropin‐releasing hormone (CRH) prior to ...
Antonis Makrigiannakis, Thomas Vrekoussis, Fanourios Makrygiannakis, Halil Ruso, Sophia N. Kalantaridou, Timur Gurgan   +5 more
openaire   +4 more sources

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source